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Concept explainers
(a)
Interpretation:
The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.
Concept Introduction:
PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial
(b)
Interpretation:
The activity of PDH should be determined in the patients who are treated with DCA.
Concept Introduction:
PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.
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Chapter 17 Solutions
Biochemistry
- Calculate pH of a solution prepared by dissolving 1.60g of sodium acetate, in 88.5 mL of 0.10 M acetic acid. Assume the volume change upon dissolving the sodium acetate is negligible. Ka is 1.75 x 10^-5arrow_forwardShow a mechanism that leads to the opening of the ring below under acid-catalyzed conditions. Give the correct Fischer projection for this sugar.arrow_forwardWhat is the stereochemical relationship between B & C?arrow_forward
- Don't use ai or any chat gpt will dislike okk just use accurate information okkk okkk just solve full accurate. don't use guidelines okk just did it accurate 100% sure experts solve it correct complete solutions okkk follow all instructions requirements okkkarrow_forwardhow would you make this plot in excel?arrow_forwardwhat is the productarrow_forward
- Balance the following equation and list of coefficients in order from left to right. SF4+H2O+—-> H2SO3+HFarrow_forwardProblem 15 of 15 Submit Using the following reaction data points, construct Lineweaver-Burk plots for an enzyme with and without an inhibitor by dragging the points to their relevant coordinates on the graph and drawing a line of best fit. Using the information from this plot, determine the type of inhibitor present. 1 mM-1 1 s mM -1 [S]' V' with 10 μg per 20 54 10 36 20 5 27 2.5 23 1.25 20 Answer: |||arrow_forward12:33 CO Problem 4 of 15 4G 54% Done On the following Lineweaver-Burk -1 plot, identify the by dragging the Km point to the appropriate value. 1/V 40 35- 30- 25 20 15 10- T Км -15 10 -5 0 5 ||| 10 15 №20 25 25 30 1/[S] Г powered by desmosarrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningHuman Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
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