Biochemistry
Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Chapter 17, Problem 14P
Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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