Chapter 17, Problem 24P

Interpretation Introduction

Interpretation:

The reason malonic acid act as a competitive inhibitor and not a substrate for succinate dehydrogenase should be determined.

Effect on the concentration of intermediates of the cycle, after the addition of malonic acid to citric acid cycle, should be determined.

Concept introduction:

The citric acid cycle is a catabolic process. It is a series of chemical reactions in which the stored energy of the body is released by the oxidation of acetyl-Coenzyme A. Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.