Biochemistry
Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Chapter 17, Problem 17P
Interpretation Introduction

(a)

Interpretation:

The effect of a mutation that increases the kinase activity which is linked with the pyruvate dehydrogenase complex.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(b)

Interpretation:

The effect of a mutation that reduces the phosphatase activity which is linked with the pyruvate dehydrogenase complex.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

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