(a) Interpretation:
The effect of the citric acid cycle intermediates isocitrate and a-ketoglutarate on glucose-stimulated exocytosis.
Concept introduction:
The glucose-stimulated insulin secretion is the hallmark feature of the differentiated beta cells of the pancreas. The rise in the glucose levels in the blood stimulate these beta cells to secrete insulin. The glucose diffuses into the cytoplasm through the transport proteins. The processing of this glucose there leads to the increase in the cytosolic Ca2+. This is vital in facilitating the two phases of the release of insulin-containing granules.
(b) Interpretation:
The effect of treatment with NADPH or NADH on the glucose-stimulated exocytosis.
Concept introduction:
The glucose-stimulated insulin secretion is the hallmark feature of the differentiated beta cells of the pancreas. The rise in the glucose levels in the blood stimulate these beta cells to secrete insulin. The glucose diffuses into the cytoplasm through the transport proteins. The processing of this glucose there leads to the increase in the cytosolic Ca2+. This is vital in facilitating the two phases of the release of insulin-containing granules.
(c) Interpretation:
The role of cytosolic isocitrate dehydrogenase.
Concept introduction:
The glucose-stimulated insulin secretion is the hallmark feature of the differentiated beta cells of the pancreas. The rise in the glucose levels in the blood stimulate these beta cells to secrete insulin. The glucose diffuses into the cytoplasm through the transport proteins. The processing of this glucose there leads to the increase in the cytosolic Ca2+. This is vital in facilitating the two phases of the release of insulin-containing granules.
(d) Interpretation:
The proposition of a metabolic pathway that starts with pyruvate and ends with GSH.
Concept introduction:
The glucose-stimulated insulin secretion is the hallmark feature of the differentiated beta cells of the pancreas. The rise in the glucose levels in the blood stimulate these beta cells to secrete insulin. The glucose diffuses into the cytoplasm through the transport proteins. The processing of this glucose there leads to the increase in the cytosolic Ca2+. This is vital in facilitating the two phases of the release of insulin-containing granules.
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Biochemistry: Concepts and Connections (2nd Edition)
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