Chapter 16, Problem 25CQ

(a)

Summary Introduction

To determine: The amino acid, other than alanine, can be converted by transamination to a gluconeogenic precursor.

Concept introduction: Gluconeogenesis is a series of chemical reactions, in which glucose is synthesized from non-carbohydrate precursors such as pyruvate, oxaloacetate glycerol, and lactate. It occurs in the liver and kidney cortex of higher animals. Transamination involves the transfer of amino group to an α-keto acid to yield the α-keto derivatives of amino acids and corresponding amino acid forms.

(b)

Summary Introduction

To calculate: The cost in ATP equivalents of converting two molecules of aspartate to one molecule of glucose.

Concept introduction: Gluconeogenesis is a series of chemical reactions, in which glucose is synthesized from non-carbohydrate precursors such as pyruvate, oxaloacetate glycerol, and lactate. It occurs in the liver and kidney cortex of higher animals. Transamination involves the transfer of amino group to an α-keto acid to yield the α-keto derivatives of amino acids and corresponding amino acid forms.