ANATOMY+PHYSIOLOGY >LOOSE<
8th Edition
ISBN: 9781308329826
Author: SALADIN
Publisher: MCG/CREATE
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Textbook Question
Chapter 1.6, Problem 19BYGO
Explain why positive feedback is more likely than negative feedback to disturb homeostasis.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 1 Solutions
ANATOMY+PHYSIOLOGY >LOOSE<
Ch. 1.1 - What is the difference between anatomy and...Ch. 1.1 - Name the method that would be used for each of the...Ch. 1.1 - The meanings of anatomy and physiology and what it...Ch. 1.1 - Prob. 2AYLOCh. 1.1 - Branches of anatomy that study the body at...Ch. 1.1 - How comparative physiology advances the...Ch. 1.2 - In what way did the followers of Galen disregard...Ch. 1.2 - Prob. 4BYGOCh. 1.2 - How is our concept of human form and function...Ch. 1.2 - Greek and Roman scholars who first gave medicine a...
Ch. 1.2 - Prob. 2AYLOCh. 1.2 - Why medical science today owes such a great debt...Ch. 1.2 - How Schleiden and Schwann revolutionized and...Ch. 1.3 - Describe the general process involved in the...Ch. 1.3 - Describe some sources of potential bias in...Ch. 1.3 - Is there more information in an individual...Ch. 1.3 - How philosophers Bacon and Descartes...Ch. 1.3 - Prob. 2AYLOCh. 1.3 - Prob. 3AYLOCh. 1.3 - The qualities of a valid scientific hypothesis,...Ch. 1.3 - How each of the following contributes to the...Ch. 1.3 - The distinctions between scientific facts, laws,...Ch. 1.4 - Define adaptation and selection pressure. Why are...Ch. 1.4 - Prob. 10BYGOCh. 1.4 - Select two other human characteristics and explain...Ch. 1.4 - The meanings of evolution, natural selection,...Ch. 1.4 - The historical origin of the theory of natural...Ch. 1.4 - How the kinship among all species is relevant to...Ch. 1.4 - Ecological conditions thought to have selected for...Ch. 1.4 - Prob. 5AYLOCh. 1.5 - Prob. 12BYGOCh. 1.5 - Prob. 13BYGOCh. 1.5 - Why is reductionism a necessary out not sufficient...Ch. 1.5 - Prob. 15BYGOCh. 1.5 - Prob. 1AYLOCh. 1.5 - Prob. 2AYLOCh. 1.5 - Examples of why the anatomy presented in textbooks...Ch. 1.6 - List four Etiological criteria of life and one...Ch. 1.6 - What is meant by dynamic equilibrium? Why would it...Ch. 1.6 - Prob. 18BYGOCh. 1.6 - Explain why positive feedback is more likely than...Ch. 1.6 - Prob. 20BYGOCh. 1.6 - Eight essential qualities that distinguish living...Ch. 1.6 - Prob. 2AYLOCh. 1.6 - Prob. 3AYLOCh. 1.6 - The clinical importance of physiological variation...Ch. 1.6 - Prob. 5AYLOCh. 1.6 - Prob. 6AYLOCh. 1.6 - Prob. 7AYLOCh. 1.6 - The concept of matter and energy flowing down...Ch. 1.7 - Explain why modern anatomical terminology is so...Ch. 1.7 - Distinguish between an eponym and an acronym, and...Ch. 1.7 - Prob. 23BYGOCh. 1.7 - Prob. 24BYGOCh. 1.7 - Prob. 1AYLOCh. 1.7 - How to break biomedical terms into familiar roots,...Ch. 1.7 - Prob. 3AYLOCh. 1.7 - Prob. 4AYLOCh. 1.7 - Why precision in spelling and usage of medical...Ch. 1.8 - A description of six core themes of this book:...Ch. 1 - Prob. 1TYRCh. 1 - Prob. 2TYRCh. 1 - The simplest structures considered to be alive are...Ch. 1 - Which of the following people revolutionized the...Ch. 1 - Which of the following embodies the greatest...Ch. 1 - Prob. 6TYRCh. 1 - A self-amplifying chain of physiological events is...Ch. 1 - Which of the following is not a human organ...Ch. 1 - ______ means studying anatomy by touch. a. Gross...Ch. 1 - The prefix hetero- means a. same. b. different. c....Ch. 1 - Cutting and separating tissues to reveal...Ch. 1 - A difference in chemical concentration between one...Ch. 1 - Prob. 13TYRCh. 1 - Physiological effects of a persons mental state...Ch. 1 - The tendency of the body to maintain stable...Ch. 1 - Blood pH averages 7.4 but fluctuates from 7.35 to...Ch. 1 - Prob. 17TYRCh. 1 - Prob. 18TYRCh. 1 - Prob. 19TYRCh. 1 - Prob. 20TYRCh. 1 - Prob. 1BYMVCh. 1 - Prob. 2BYMVCh. 1 - Prob. 3BYMVCh. 1 - metabolo-Ch. 1 - Prob. 5BYMVCh. 1 - physio-Ch. 1 - Prob. 7BYMVCh. 1 - Prob. 8BYMVCh. 1 - Prob. 9BYMVCh. 1 - tomo-Ch. 1 - Prob. 1WWTSCh. 1 - Prob. 2WWTSCh. 1 - Prob. 3WWTSCh. 1 - Prob. 4WWTSCh. 1 - Matter does not generally move down a gradient in...Ch. 1 - Prob. 6WWTSCh. 1 - Prob. 7WWTSCh. 1 - Prob. 8WWTSCh. 1 - Human evolution is basically a theory that humans...Ch. 1 - Prob. 10WWTSCh. 1 - Ellen is pregnant and tells Janet, one of her...Ch. 1 - Which of the characteristics of living things are...Ch. 1 - About 1 out of every 120 live-born infants has a...Ch. 1 - How might human anatomy be different today if the...Ch. 1 - Prob. 5TYC
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