Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Textbook Question
Chapter 16, Problem 16P
What would be the effect on fatty acid synthesis of an increase in intramitochondrial oxaloacetate level? Briefly explain your answer
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Chapter 16 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 16 - Prob. 1PCh. 16 - If palmitic acid is subjected to complete...Ch. 16 - Calculate the number of ATPs generated by the...Ch. 16 - Prob. 4PCh. 16 - Prob. 5PCh. 16 - Under conditions where ketone bodies are being...Ch. 16 - Prob. 7PCh. 16 - 2-Bromopalmitoyl-CoA inhibits the oxidation of...Ch. 16 - When the identical subunits of chicken liver fatty...Ch. 16 - Prob. 10P
Ch. 16 - Prob. 11PCh. 16 - Prob. 12PCh. 16 - Prob. 13PCh. 16 - Prob. 14PCh. 16 - Prob. 15PCh. 16 - What would be the effect on fatty acid synthesis...Ch. 16 - Prob. 17PCh. 16 - Identify and briefly discuss each mechanism...Ch. 16 - Prob. 19PCh. 16 - Prob. 20PCh. 16 - Prob. 21PCh. 16 - Prob. 22PCh. 16 - Prob. 23PCh. 16 - 24. If mevalonate labeled with 14C in the carboxyl...Ch. 16 - Prob. 25PCh. 16 - Identify a pathway for utilization of the four...Ch. 16 - Prob. 27PCh. 16 - cis-Vaccenate is an 18-carbon unsaturated fatty...Ch. 16 - 29. Briefly describe how cyclic AMP controls...Ch. 16 - Prob. 30PCh. 16 - Prob. 31PCh. 16 - In addition to the pathway described in Figure...Ch. 16 - Prob. 33P
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- What impact would an increase in intramitochondrial oxaloacetate have on fatty acid synthesis? Justify your response succinctly.arrow_forwardIn the fasted state, FADH2 and NADH for oxidative phosphorylation are mainly provided by fatty acid oxidation. Explain how fatty acids are mobilised from adipose tissue by the action of glucagon.arrow_forwardIn type I diabetes mellitus, excessive production of acetyl-CoA may surpass the body’s capacity to oxidize it. As a result, acetoacetate, β-hydroxybutyrate, and acetone (ketone bodies) accumulate. When generated in large amounts, blood pH falls, thereby reducing the capacity of red blood cells to carry oxygen. Explain in general terms how high concentrations of ketone bodies may result in a fatal coma.arrow_forward
- Explain why triglycerides have a glucose-sparing effect.arrow_forwardPancreatic β cells express a receptor for fatty acids. Fatty acid binding to the protein appears to stimulate insulin secretion. Does this phenomenon make metabolic sense?arrow_forwardGlucagon is released from the pancreas in response to low blood glucose levels. It regulates the opposing pathways of glycolysis and gluconeogenesis by altering levels of fructose 2,6-bisphosphate. If glucagon causes a decrease in fructose 2,6-bisphosphate, how does this increase blood glucose levels? Explain..arrow_forward
- In order for a fatty acid stored in an adipocyte to be oxidized by a muscle cell, which of the following will need to be present/utilized? Check all that apply. Multiple answers can be selected Acyl CoA Synthetase CD36 malate-aspartate shuttle dephosphorylated hormone-sensitive lipase GLUT 4arrow_forwardHow many ATP are produced from a triglyceride containing three 14 carbon fatty acids? NOTE: Assume that glycerol is converted to Glyceraldehyde-3-Phosphate (step 6 of glycolysis).arrow_forwardWrite a one-sentence explanation for each of the following statements. (a) In liver, glucagon stimulates glycogen breakdown via cyclic AMP. Although one might expect glucagon also to stimulate catabolism of the glucose formed, glucagon inhibits glycolysis and stimulates glu- coneogenesis in liver. (b) An individual with a glucose-6-phosphatase deficiency suffers from chronic hypoglycemia. (c) The action of phosphorylase kinase simultaneously activates glycogen breakdown and inhibits glycogen synthesis. (d) The presence in liver of glucose-6-phosphatase is essential to the function of the liver in synthesizing glucose for use by other tissues.arrow_forward
- Describe the sources and fates of acetyl CoAarrow_forwardHow is the usage of fat as an energy source regulated? What would you expect to be the effect ofcaffeine or theophylline on fatty acid mobilization?arrow_forwardWhat effect is observed on the rate of gluconeogenesis under each of the following conditions? a. low ATP concentrationc. high carbohydrate diet b. low ADP concentrationd. low carbohydrate dietarrow_forward
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