(a) Interpretation:
The compound(s) which become labeled during the reaction and the compounds in which
Concept introduction:
The first step in fatty acid synthesis is carboxylation dependent on ATP of acetyl-CoA to malonyl-CoA. The next steps in reaction are formation of Malonyl-ACP and acetyl-ACP.
Biosynthesis of fatty acid requires seven cycles of
(b) Interpretation:
The role of citrate in the reaction of the conversion of acetyl-CoA to palmitate and CoASH if supplied with
Concept introduction:
Earlier studies showed activities of acetyl-CoA carboxylase and the first step of fatty acid synthesis can be modified by various metabolites. The malonyl-CoA formation is the first step in fatty acid synthesis and was considered to be the rate limiting step and citrate or isocitrate could affect the activity or
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Biochemistry: Concepts and Connections (2nd Edition)
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