Chapter 16, Problem 16.47CP

(a)

Interpretation Introduction

Interpretation:

It should be described that how the given structure of $sodiumsulfanilamide$ similar to the structure of $\text{p-}\text{aminobenzoic}\text{acid}$.

Concept introduction:

In chemistry Structure is the arrangement of chemical bonds between atoms in a molecule, specifically which atoms are chemically bonded to what other atoms with what kind of chemical bond.

Amines are the derivatives of ammonia $\left(N{H}_3\right)$ with one or more of the hydrogens replaced with a substituent such as an alkyl group.

Sulfanilamide is an antibacterial which contains a sulfonamide group.

(b)

Interpretation Introduction

Interpretation:

Usually sodium salt is used as the drug rather than the neutral compound; the reason behind this should be explained.

Concept introduction:

The formation of salt involves either a proton transfer or a neutralization reaction between an acid and a base.

Drug solubility and dissolution rate greatly affect the absorption of drug.

The salt form of a drug is usually more soluble than the parent drug.