The reactions involved in the process where the products of pyrimidine base catabolism are degraded to succinyl CoA (coenzyme A) and acetyl CoA. Introduction: The degradation of pyrimidine bases includes the conversion of uracil and thymine to β-alanine and β-aminoisobutyrate, respectively. These two conversion pathways run parallel to each other. The first step involves the reduction of uracil and thymine by dihydropyrimidine dehydrogenase. The products are hydrolyzedand the open rings of β-ureidopropionate and β-ureidoisobutyrate are formed. These molecules further degrade to form succinyl CoA and acetyl CoA.

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Chapter 15, Problem 7Q

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The reactions involved in the process where the products of pyrimidine base catabolism are degraded to succinyl CoA (coenzyme A) and acetyl CoA.

Introduction:

The degradation of pyrimidine bases includes the conversion of uracil and thymine to β-alanine and β-aminoisobutyrate, respectively. These two conversion pathways run parallel to each other. The first step involves the reduction of uracil and thymine by dihydropyrimidine dehydrogenase. The products are hydrolyzedand the open rings of β-ureidopropionate and β-ureidoisobutyrate are formed. These molecules further degrade to form succinyl CoA and acetyl CoA.

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