Chapter 14, Problem 9TYU

Summary Introduction

To determine: The probability of birth of a child with sickle-cell disease, if both spouses are predicted to be carriers of recessive allele causing sickle-cell disease.

Concept introduction:

During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation. After the genetic crossing, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules. Since sickle-cell disease is an autosomal recessive disease, it shows its effect only in the homozygous recessive genotype.