Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
10th Edition
ISBN: 9780133922851
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 14.4, Problem 2CC
Summary Introduction

To explain: The change in the single amino acid in hemoglobin that results in the aggregation of hemoglobin in long fibers.

Concept introduction:

The primary structure of proteins is the linear sequence of amino acids. It determines the shape and the functional ability of the protein. A small change in the amino acid sequence can alter a protein’s shape and its functions.

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4. You are to choose the members of an expedition that will climb several high mountains. Each applicant for one of the positions is a heterozygote for an abnormal hemoglobin: Person A: Hb Albany: a methionine has been substituted for Lys 82 in the B-subunit. Person B: Hb Cowtown: a leucine has been substituted for His 146 in the B-subunit. Person C: Hb Flagstaff: an isoleucine has been substituted for Val 1 in the B-subunit. For the locations of the amino acid residues refer to your text, the figure on page 9 of this lab, and the KING exercises. Assuming that each of these candidates is equal in ability at low altitude, which one would you choose for the expedition? To answer this question, determine how the substituted amino acid affects the structure and function of each abnormal hemoglobin, and describe the physiological effect. Focus on the stabilization of the T versus R state of hemoglobin, and the consequent physiological changes that might occur altitude. Keep your answers…
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Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)

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