(a)
To determine: The probability of different probable genotypes in offspring if the man and his wife both are carriers of the recessive allele causing phenylketonuria (PKU).
Concept introduction: During gamete formation, two alleles of a gene segregate into different gametes. This is based on the Mendel’s law of segregation. After the genetic cross, the allele combinations are predicted that determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules.
(b)
To evaluate: The probability of one or more of the three children having disease.
Concept introduction: During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation. After the genetic cross, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules.
(c)
To evaluate: The probability of all three children having disease.
Concept introduction: During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation. After the genetic cross, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules.
(d)
To evaluate: The probability of one child having a normal phenotype.
Concept introduction: During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation. After the genetic cross, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules.
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