Exercise Physiology: Theory and Application to Fitness and Performance
10th Edition
ISBN: 9781259870453
Author: Scott K Powers, Edward T Howley
Publisher: McGraw-Hill Education
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Chapter 13, Problem 3O
Summary Introduction
To describe: The typical changes in VO2 with endurance training programs and the effect of the initial value on the magnitude of the increase.
Introduction: The act of exercising that includes aerobic system opposed to anaerobic system is called endurance exercise. It refers to the maximal oxygen uptake or maximal aerobic power, which denotes the ability of the body to transport and utilize oxygen at the time of exercise.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 13 Solutions
Exercise Physiology: Theory and Application to Fitness and Performance
Ch. 13 - Prob. 1OCh. 13 - Discuss the role that genetics plays in...Ch. 13 - Describe the typical change in max with...Ch. 13 - Prob. 4OCh. 13 - Prob. 5OCh. 13 - Prob. 6OCh. 13 - Define preload, afterload, and contractility, and...Ch. 13 - Prob. 8OCh. 13 - Prob. 9OCh. 13 - Prob. 10O
Ch. 13 - Prob. 11OCh. 13 - Prob. 12OCh. 13 - Prob. 13OCh. 13 - Outline the signaling events that lead to...Ch. 13 - Prob. 15OCh. 13 - Prob. 16OCh. 13 - Prob. 17OCh. 13 - Prob. 18OCh. 13 - Prob. 19OCh. 13 - Discuss how detraining following strength training...Ch. 13 - Prob. 21OCh. 13 - Prob. 1SACh. 13 - Prob. 2SACh. 13 - Prob. 3SACh. 13 - Prob. 4SACh. 13 - Prob. 5SACh. 13 - Prob. 6SACh. 13 - Prob. 7SACh. 13 - Prob. 8SACh. 13 - List and discuss the primary changes that occur in...Ch. 13 - Prob. 10SACh. 13 - Prob. 11SACh. 13 - Prob. 12SACh. 13 - Prob. 13SACh. 13 - Prob. 14SACh. 13 - Prob. 15SACh. 13 - Prob. 16SACh. 13 - Prob. 17SACh. 13 - Prob. 18SACh. 13 - Prob. 19SACh. 13 - Prob. 20SACh. 13 - Prob. 21SACh. 13 - Explain why concurrent strength and endurance...
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