Chapter 13, Problem 13.24P

Interpretation Introduction

Interpretation:

It is to be determined among aprotic solvents DMSO and DMF, which is best suitable for ${\text{S}}_{\text{N}}\text{2}$ reaction, based on their toxicity.

Concept introduction:

Polar aprotic solvents do not stabilize nucleophiles as much as polar protic solvents do’ thus polar aprotic solvents tend to favor ${\text{S}}_{\text{N}}\text{2}$ reactions. As a safety precaution, it is better to use less toxic solvents for the reactions.