Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 12.7, Problem 4RIA
Activated carriers participate in carbohydrate, peptidoglycan, lipid, and LPS synthesis. Briefly describe these carriers and their roles. Are there any features common to all the carriers? Explain your answer.
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. The mechanism for lysozyme cleavage of its polysaccharide substrate requires Glu35 in its
nonionized form, whereas the nearby Asp52 must be ionized (see the figure below). The pK
values for the side-chain carboxyl groups on the two amino acids in solution are virtually
identical.
a) How can one carboxyl group be charged and the other uncharged in the active site of
lysozyme?
b) The pH optimum for lysozyme is about 5. Why do you suppose that the activity decreases
above and below this optimum?
Glu3s
NAG
Asp52
0-H
Glu35 -C
Asp52
tri-NAG
NAG
A) Upon entering the body, CH3H9+ reacts
with cysteine to form a molecule that is
able to pass through the blood brain barrier
(BBB). Draw the structure of this molecule
and purpose why it is able to pass through
the BBB (Hint: think about another amino
acid). B) The adduct formed in part A is very
labile. On encountering selenocysteine, it
can permanently inhibit it. Propose how the
adduct from Part A inhibits selenocysteine
and explain your answer.
Mucins found on adenocarcinoma cells carry O-glycans terminated with sialic acids (such as the Sialyl Tn antigen) that are smaller and less branched than O-glycans found in healthy epithelial cells. Based on what you know about the biosynthetic pathway for O-glycans, explain this observation.
Chapter 12 Solutions
Prescott's Microbiology
Ch. 12.1 - Prob. 1RIACh. 12.1 - Retrieve, Infer, Apply What is self-assembly? What...Ch. 12.3 - Retrieve, Infer, Apply Briefly describe the three...Ch. 12.3 - Retrieve, Infer, Apply Which two enzymes are...Ch. 12.4 - MICRO INQUIRY How might acetyl-CoA be used by the...Ch. 12.4 - Prob. 2MICh. 12.4 - MICROINQUIRY What is the difference between Lipid...Ch. 12.4 - Retrieve, Infer, Apply What is gluconeogenesis?...Ch. 12.4 - Retrieve, Infer, Apply Describe the formation of...Ch. 12.4 - Retrieve, Infer, Apply Suppose a microorganism is...
Ch. 12.4 - Retrieve, Infer, Apply Diagram the steps involved...Ch. 12.4 - Retrieve, Infer, Apply What would happen to a cell...Ch. 12.5 - What purpose is served for the cell when these...Ch. 12.5 - Prob. 2MICh. 12.5 - Prob. 1RIACh. 12.5 - How is nitrate assimilated? How does assimilatory...Ch. 12.5 - Prob. 3RIACh. 12.5 - How do organisms assimilate sulfur? How does...Ch. 12.5 - Prob. 5RIACh. 12.5 - Prob. 6RIACh. 12.5 - Describe the glyoxylate cycle. How is it similar...Ch. 12.5 - Prob. 8RIACh. 12.5 - List the types of organisms that use each...Ch. 12.6 - How is phosphorus assimilated? What roles do...Ch. 12.6 - Explain the difference between a purine and a...Ch. 12.6 - Outline the way in which purines and pyrimidines...Ch. 12.7 - Prob. 1RIACh. 12.7 - How are unsaturated fatty acids made?Ch. 12.7 - Briefly describe the pathways for triacylglycerol...Ch. 12.7 - Activated carriers participate in carbohydrate,...Ch. 12.7 - Prob. 5RIACh. 12 - What would happen if a microorganism that depended...Ch. 12 - Intermediary carriers are in a limited supply:...Ch. 12 - Magnetotactic bacteria are morphologically and...
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