The general physical property of alkanes has to be chosen from the given set of options. Concept Introduction: Organic compounds are represented shortly by the molecular formula and structural formula. Each and every compound has its own molecular formula. Compounds can have same molecular formula but not same structural formula. Alkanes are linear chain saturated hydrocarbons and cycloalkanes are cyclic carbon chain saturated hydrocarbons. They both occur naturally. Alkanes and cycloalkanes are hydrocarbons. They are nonpolar molecules. Water is a polar molecule. Therefore, alkanes and cycloalkanes do not get solubilized in water. In other words, alkanes and cycloalkanes are insoluble in water. Regarding density, alkanes and cycloalkanes have density lower than water. When alkanes and cycloalkanes are mixed with water, two layers are formed which is a result of insolubility. Alkanes and cycloalkanes are present on top of water layer which is due to lesser density. Boiling point of alkanes and cycloalkanes increase with an increase in carbon‑chain length or the ring size. When considering the continuous‑chain alkanes, the boiling point of alkanes increases about 30 ° C for every carbon atom that is added to the chain. The continuous alkanes which contain one to four carbon atoms are gases at room temperature. The continuous chain alkanes that contain five to seventeen carbon atoms are liquids at room temperature. The continuous chain alkanes that contain more than eighteen carbon atoms are solids at room temperature. When branching happens in the carbon chain, it lowers the boiling point of alkanes. In simple words, unbranched alkanes have more boiling point than branched alkanes with the same number of carbon atoms. Cycloalkanes have more boiling point compared to noncyclic alkanes with the same number of carbon atoms. This is due to the more rigid and more symmetrical structures that occur in cyclic systems. Cyclopropane and cyclobutane are gases at room temperature. Cyclopentane to cyclooctane are liquids at room temperature.

Question

1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

Answer 1

Question

Chapter 12.16, Problem 1QQ

Interpretation Introduction

Interpretation:

The general physical property of alkanes has to be chosen from the given set of options.

Concept Introduction:

Organic compounds are represented shortly by the molecular formula and structural formula. Each and every compound has its own molecular formula. Compounds can have same molecular formula but not same structural formula.

Alkanes are linear chain saturated hydrocarbons and cycloalkanes are cyclic carbon chain saturated hydrocarbons. They both occur naturally.

Alkanes and cycloalkanes are hydrocarbons. They are nonpolar molecules. Water is a polar molecule. Therefore, alkanes and cycloalkanes do not get solubilized in water. In other words, alkanes and cycloalkanes are insoluble in water.

Regarding density, alkanes and cycloalkanes have density lower than water. When alkanes and cycloalkanes are mixed with water, two layers are formed which is a result of insolubility. Alkanes and cycloalkanes are present on top of water layer which is due to lesser density.

Boiling point of alkanes and cycloalkanes increase with an increase in carbon‑chain length or the ring size. When considering the continuous‑chain alkanes, the boiling point of alkanes increases about 30 °C for every carbon atom that is added to the chain. The continuous alkanes which contain one to four carbon atoms are gases at room temperature. The continuous chain alkanes that contain five to seventeen carbon atoms are liquids at room temperature. The continuous chain alkanes that contain more than eighteen carbon atoms are solids at room temperature.

When branching happens in the carbon chain, it lowers the boiling point of alkanes. In simple words, unbranched alkanes have more boiling point than branched alkanes with the same number of carbon atoms.

Cycloalkanes have more boiling point compared to noncyclic alkanes with the same number of carbon atoms. This is due to the more rigid and more symmetrical structures that occur in cyclic systems. Cyclopropane and cyclobutane are gases at room temperature. Cyclopentane to cyclooctane are liquids at room temperature.

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