Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 12, Problem 8PDQ
Describe the sequence of research findings that led to the development of the model of chromatin structure.
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Chapter 12 Solutions
Concepts of Genetics (12th Edition)
Ch. 12 - In bacteriophages and bacteria, the DNA is almost...Ch. 12 - After salivary gland cells from Drosophila are...Ch. 12 - If a human nucleus is 10 m in diameter, and it...Ch. 12 - Roberts syndrome is a rare inherited disorder...Ch. 12 - Prob. 2CSCh. 12 - Roberts syndrome is a rare inherited disorder...Ch. 12 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 12 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 12 - Contrast the size of the single chromosome in...Ch. 12 - Describe the structure of giant polytene...
Ch. 12 - What genetic process is occurring in a puff of a...Ch. 12 - During what genetic process are lampbrush...Ch. 12 - Why might we predict that the organization of...Ch. 12 - Describe the sequence of research findings that...Ch. 12 - Describe the molecular composition and arrangement...Ch. 12 - Describe the transitions that occur as nucleosomes...Ch. 12 - Provide a comprehensive definition of...Ch. 12 - Mammals contain a diploid genome consisting of at...Ch. 12 - Assume that a viral DNA molecule is a 50-m-long...Ch. 12 - How many base pairs are in a molecule of phage T2...Ch. 12 - Examples of histone modifications are acetylation...Ch. 12 - Contrast the structure of SINE and LINE DNA...Ch. 12 - Variable number tandem repeats (VNTRs) are...Ch. 12 - It has been shown that infectious agents such as...Ch. 12 - Cancer can be defined as an abnormal proliferation...Ch. 12 - In a study of Drosophila, two normally active...Ch. 12 - Prob. 21ESPCh. 12 - An article entitled Nucleosome Positioning at the...Ch. 12 - Prob. 23ESPCh. 12 - Following is a diagram of the general structure of...Ch. 12 - Microsatellites are currently exploited as markers...Ch. 12 - At the end of the short arm of human chromosome 16...
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- Discuss the following statement: “from the nucleotide sequence of a cDNA clone, the complete amino acid sequence of a protein can be deduced by applying the genetic code. thus, protein biochemistry has become superfluous because there is nothing more that can be learned by studying the protein.”arrow_forwardAn explorer discovers a strange new species of plant and sends some of the plant tissue to a geneticist to study. The geneticist isolates chromatin from the plant and examines it with an electron microscope. She observes what appear to be beads on a string. She then adds a small amount of nuclease, which cleaves the string into individual beads that each contain 280 bp of DNA. After digestion with more nuclease, a 120bp fragment of DNA remains attached to a core of histone proteins. Analysis of the histone core reveals histones in the following proportions: H1 12.5% H2A 25% H2B 25% H3 0% H4 25% H7 (a new histone) 12.5% On the basis of these observations, what conclusions could the geneticist make about the probable structure of the nucleosome in the chromatin of this plant?arrow_forwardYou are interested in studying a gene called pumper that is important for heart function. The pumper gene is only expressed (transcribed) in heart cells, and you think the reason for this may have to do with chromatin structure. To investigate this, you isolate chromatin from heart cells and skin cells, and perform a long digestion of both samples with DNAse I, a non-sequence specific enzyme that will cut the phosphodiester bonds linking adjacent nucleotides. You then remove all proteins and analyze the DNA by gel-electrophoresis. You are able to detect only the DNA fragments that contain the pumper gene. The bands at the top of lane 2 indicate very large DNA fragments that were not able to migrate very far in the gel. The numbers to the left indicate where in the gel DNA fragments of the indicated size would migrate. Based on this data, which of the following is likely to be TRUE regarding the pumper locus in heart cells? (select all that apply) hyper-acetylation of lysine on Histone…arrow_forward
- An explorer discovers a strange new species of plant and sends some of the plant tissue to a geneticist to study. The geneticist isolates chromatin from the plant and examines it with an electron microscope. She observes what appear to be beads on a string. She then adds a small amount of nuclease, which cleaves the string into individual beads that each contain 280 bp of DNA. After digestion with more nuclease, a 120- bp fragment of DNA remains attached to a core of histone proteins. Analysis of the histone core reveals histones in the following proportions: H1 12.5% H2A 25% H2B 25% H3 0% H4 25% H7 (a new histone) 12.5% On the basis of these observations, what conclusions could the geneticist make about the probable structure of the nucleosome in the chromatin of this plant?arrow_forwardThe picture below depicts electron micrographs of the major levels of chromatin structure. Match each of the listed conditions with the most likely levels of chromatin structure under that condition.arrow_forwardDescribe briefly the five levels of DNA packaging in the nucleus. Explain two purposes of these many levels of genome architecture.arrow_forward
- Describe constitutive heterochromatin and facultative heterochromatin. Based upon this information, what would you predict would happen during the embryonic development of an organism if some regions of facultative heterochromatin were changed to constitutive regions?arrow_forwardgive 2 examples of molecular machine except for replisome, transcriptome, ribosome and spliceosome.arrow_forwardDescribe the steps of the chromatin immunoprecipitation assay. What are some of the scientific facts that can be learned through a chromatin immunoprecipitation assay?arrow_forward
- The technique of fluorescence in situ hybridization (FISH) is described. This is another method for examining sequence complexity within a genome. In this method, a DNA sequence, such as a particular gene sequence, can be detected within an intact chromosome by using a DNA probe that is complementary to the sequence.For example, let’s consider the β-globin gene, which isfound on human chromosome 11. A probe complementary to theβ-globin gene binds to that gene and shows up as a brightly colored spot on human chromosome 11. In this way, researchers can detectwhere the β-globin gene is located within a set of chromosomes. Becausethe β-globin gene is unique and because human cells are diploid(i.e., have two copies of each chromosome), a FISH experimentshows two bright spots per cell; the probe binds to each copy ofchromosome 11. What would you expect to see if you used thefollowing types of probes?A. A probe complementary to the Alu sequenceB. A probe complementary to a tandem array near…arrow_forward"Complementary DNA (cDNA) libraries offer certain advantages over genomic libraries". Explain how ?arrow_forwardIn the DNA model, what are the features that contribute to the stability and the ability of the DNA to replicate faithfully?arrow_forward
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