Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 12, Problem 35P
Summary Introduction

To analyze:

An inducible operon of bacteria has three genes R, T, and S – same as lactose operon. These genes play a role in the regulation of transcription. These genes can be operator gene, regulatory gene, and structural gene (codes for structural enzyme). In the question, a table is provided in which "+" represents that the synthesis of structural enzyme is active and "-" represents no synthesis of structural enzyme. By using the given information, the question asked to determine from given genotype which gene is operator gene, which one is regulatory gene, and which one is structural gene.

Introduction:

A unit of DNA that has a group of genes controlled by a single promoter is termed as an operon. The operon possesses different regions (operator, promoter and structural genes); each region has a different role. Operator region is a short region of operon that controls transcription of genes by interacting with regulatory proteins. Regulatory proteins include proteins that act as transcription factor and facilitate the synthesis of protein in bacteria. Any protein which has its impact on the region of operon (DNA), which is transcribed in the transcription, is a regulatory protein.

The gene which codes for the protein other than the regulatory protein is termed as the structural gene. The product of structural genes is structural protein and enzymes.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.

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Genetic Analysis: An Integrated Approach (3rd Edition)

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Bacterial Genomics and Metagenomics; Author: Quadram Institute;https://www.youtube.com/watch?v=_6IdVTAFXoU;License: Standard youtube license