Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 12, Problem 3P
Why is it essential that bacterial cells be able to regulate the expression of their genes? What are the energetic and evolutionary advantages of regulated gene expression? Is the expression of all bacterial genes subject to regulated expression? Compare and contrast the difference between regulated gene expression and constitutive gene expression.
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Which of the following is NOT a reason cells regulate gene expression at a level other than the transcriptional level?
Some proteins are only required in part of the cell and transcriptional control will only regulate the mRNA/protein throughout the cell.
The core promoter for many genes is the same, so these genes will always be transcribed in the same cells. Differential gene expression in different cell types requires
regulation of gene expression at levels other than transcription.
Transcription and translation are realtively slow processes, so cells need to regulate gene expression post-transcriptionally if they require a fast change in expression
of a gene.
Not all cells are transcriptionally active (meaning they do not transcribe any genes), so these cells need to regulate gene expression post-transcriptionally.
The most common type of regulation of gene expression occurs at the level of transcription. Name other types of gene regulation for gene expression in eukaryotic cells. Name types of gene regulation unique to eukaryotic cells versus prokaryotic cells.
Compare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.
Chapter 12 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 12 - 12.1 Bacterial genomes frequently contain groups...Ch. 12 - Transcriptional regulation of operon gene...Ch. 12 - Why is it essential that bacterial cells be able...Ch. 12 - Identify similarities and differences between an...Ch. 12 - The transcription of -galactosidase and permease...Ch. 12 - 12.6 Is attenuation the product of an allosteric...Ch. 12 - The trpL region contains four repeated DNA...Ch. 12 - The CAP binding site in the lac promoter is the...Ch. 12 - What role does cAMP play in transcription of lac...Ch. 12 - How would a cap- mutation that produces an...
Ch. 12 - Explain the circumstances under which attenuation...Ch. 12 - Consider the transcription of genes of the...Ch. 12 - Describe the lytic and lysogenic life cycles of ...Ch. 12 - 12.14 Define antisense RNA, and describe how it...Ch. 12 - 12.15 Attenuation of trp operon transcription is...Ch. 12 - 12.16 In the lac operon, what are the likely...Ch. 12 - Identify which of the following lac operon haploid...Ch. 12 - Prob. 18PCh. 12 - 12.19 List possible genotypes for lac operon...Ch. 12 - Suppose each of the genotypes you listed in parts...Ch. 12 - 12.21 Four independent mutants (mutants A to D)...Ch. 12 - Suppose the lac operon partial diploid...Ch. 12 - What is a riboswitch? Describe the riboswitch...Ch. 12 - 12.24 A repressible operon system, like the trp...Ch. 12 - 12.25 What is the likely effect of each of the...Ch. 12 - 12.26 Suppose that base substitution mutations...Ch. 12 - 12.27 Two different mutations affect. Mutant...Ch. 12 - How would mutations that inactivate each of the...Ch. 12 - The bacterial insertion sequence IS 10 uses...Ch. 12 - For an E. coli strain with the lac operongenotype...Ch. 12 - 12.31 How could antisense RNA be used as an...Ch. 12 - 12.32 Section describes the function of tRNA...Ch. 12 - The following hypothetical genotypes have genes A,...Ch. 12 - 12.34 Northern blot analysis is performed on...Ch. 12 - Prob. 35PCh. 12 - Prob. 36PCh. 12 - 12.37 The electrophoresis gel shown in part (a) is...
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- IS. Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of the following is not an evolutionary advantage of alternative splicing? Alternative splicing increases diversity without increasing genome size Different gene isoforms can be expressed in different tissues Alternative splicing creates shorter mRNA transcripts Different gene isoforms can be expressed during different stages of development.arrow_forwardCreate a Venn diagram to compare and contrast the process of gene expression in Bacteria versus eukaryotes. Remember that “gene expression” can include any part of transcription or translation. Try to be as thorough as you can about what aspects of this process are similar between the two taxa, and what characteristics are distinct to only Bacteria or eukaryotes. Plase include a minimum of 15 items in the Venn diagram.arrow_forwardTranscriptional repressor proteins (e.g., lac repressor), antisense RNA, and feedback inhibition are three different mechanisms that turn off the expression of genes and gene products. Which of these three mechanisms will be most effective in each of the following situations? A. Shutting down the synthesis of a polypeptide B. Shutting down the synthesis of mRNA C. Shutting off the function of a protein For your answers to parts A–C that list more than one mechanism, which mechanism will be the fastest or the most efficient?arrow_forward
- We know that eukaryote gene regulation can occur at any point in the process of gene expression. (a) What is the final step where gene expression control may occur in the process of protein expression ? (b) Is this a cellular energy efficient or inefficient mechanism of gene regulation? Explain.arrow_forwardDiscuss the following argument: “if the expression of every gene depends on a set of transcription regulators, then the expression of these regulators must also depend on the expression of other regulators, and their expression must depend on the expression of still other regulators, and so on. cells would therefore need an infinite number of genes, most of which would code for transcription regulators.” how does the cell get by without having to achieve the impossible?arrow_forwardYou are interested in studying a novel gene that appears to be involved in cancer. There is no information about the function of this gene. What would you do to obtain the cDNA for this gene? How would you express this gene and what expression systems might you utilize to study its function and why? How would determine the subcellular localization of this gene in eukaryotic cells? What are alternative methods in case one doesn't work? How would you purify and determine the 3-dimensional structure of this protein?arrow_forward
- Choose the statement that correctly characterizes regulated and/or constitutive gene expression. Regulated expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is always repressed in response to the absence of required nutrients or other metabolic molecules. Regulated expression refers to gene expression that is always on, regardless of the metabolic or physiological conditions in the cell. Regulated and constitutive expression are terms used to describe gene expression in prokaryotes only.arrow_forwardWhich of the following is not a general description of the gene expression regulation mechanisms that operate in eukaryotic organisms? transcriptional-level control processing-level control translational level-control replication-level controlsarrow_forwardList the following steps of gene expression in eukaryotes in chronological order. Also indicate which events take place in the nucleus and which take place in the cytoplasm. RNA processing, transcription, translation, RNA breakdown into nucleotidesarrow_forward
- Two component systems are common in bacteria to regulate the expression of specific genes in response to environmental signals. Which of the following can be said of two component systems? (mark all the answers that apply) An intracellular response regulator is involved in the response. A membrane-bound sensor kinase is typically involved. A membrane transporter is required to transport a molecular signal into the cell, which then serves as an inducer of transcription for an operon. Molecules are pumped out of the cell through one molecular compnent, and transported back in through a second molecular component.arrow_forwardRegarding noncoding RNA, which of the following statements is false? HOTAIR RNA works as a scaffold that binds specific protein regulators at its two ends. Many long noncoding RNAs work in epigenetic regulation of gene expression. Most regulatory long noncoding RNAs work as trans-acting regulators. HOTAIR RNA is produced by a gene in the HOXC homeobox gene cluster at 12q13 but can regulate multiple genes within the HOXD gene cluster on chromosome 2. Noncoding RNAs are mostly involved in translation processes.arrow_forwardWhat role does an operator sequence serve in bacterial gene expression regulation? Describe one change in bacterial cells that can cause a repressor protein to go from inactive to active or from active to inactive.arrow_forward
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