The molecular defects that occur in Oguchi disease. Introduction: Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

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Answer 1

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Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

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Answer 3

Question

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

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Answer 4

Question

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

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Answer 5

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

Answer 6

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Answer 7

Chapter 12, Problem 16P

Summary Introduction

To determine: The molecular defects that occur in Oguchi disease.

Introduction:

Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

Answer 8

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

Answer 9

Summary Introduction

To determine: The molecular defect leads to cause night blindness.

Introduction:

Night blindness is defined as a condition of eyes which involves normal vision during daylight but poor vision in dim light or in night. It is caused due degeneration of rods in retina of eyes as rods are sensory cells that are responsible for vision in dim light.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 12 - Prob. 1P Ch. 12 - Prob. 2P Ch. 12 - Prob. 3P Ch. 12 - Prob. 4P Ch. 12 - Prob. 5P Ch. 12 - Prob. 6P Ch. 12 - Prob. 7P Ch. 12 - Prob. 8P Ch. 12 - Prob. 9P Ch. 12 - Prob. 10P

The molecular defects that occur in Oguchi disease. Introduction: Oguchi disease is a type of autosomal recessive disorder of retina which is characterized by congenital night blindness. Night blindness is eye disorder which is caused by nearsightedness, cataract or vitamin A deficiency.

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