The physical control methods are used to sterilize. Introduction: Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi , bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

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Answer 1

Question

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

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Answer 2

Question

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Expert Solution & Answer

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Answer 3

Question

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Expert Solution & Answer

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Answer 4

Question

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Expert Solution & Answer

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Answer 5

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Answer 6

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Answer 7

Chapter 11, Problem 1CC

Summary Introduction

To determine:

The physical control methods are used to sterilize.

Introduction:

Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Answer 8

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Answer 9

Summary Introduction

To determine:

The materials that are required for sterilization.

Introduction:

Sterilization is defined as techniques which are used for complete removal, killing or deactivation of biological agents such as fungi, bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

Answer 10

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Answer 11

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Answer 13

Ch. 11.1 - Distinguish among the terms sterilization,...Ch. 11.1 - Prob. 2AYP Ch. 11.1 - Prob. 3AYP Ch. 11.1 - Name four categories of cellular targets for...Ch. 11.2 - Prob. 5AYP Ch. 11.2 - Prob. 6AYP Ch. 11.2 - Define thermal death time and thermal death point,...Ch. 11.2 - Prob. 8AYP Ch. 11.2 - Prob. 9AYP Ch. 11.2 - Identify advantages and disadvantages of cold...

The physical control methods are used to sterilize. Introduction: Sterilization is defined as a technique which is used for complete removal, killing or deactivation of biological agents such as fungi , bacteria, viruses, and prion. These biological agents cause infections in humans and animals.

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