Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 10, Problem 5RQ
Summary Introduction
Introduction: Sensory neurons are the type of cells present in the nervous system that is responsible for converting the external stimulus to the internal electric impulse. The neurons carry information from sensory organs and send them to the central nervous system.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 10 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 10.1 - What advantage do myelinated axons provide?Ch. 10.1 - What accessory role does the outer ear (the pinna)...Ch. 10.1 - Prob. 3CCCh. 10.1 - In Figure 10.5, what kind(s) of ion channel might...Ch. 10.1 - How do sensory receptors communicate the intensity...Ch. 10.1 - Prob. 6CCCh. 10.2 - Prob. 7CCCh. 10.2 - Prob. 8CCCh. 10.2 - Your sense of smell uses phasic receptors. What...Ch. 10.3 - Create a map or diagram of the olfactory pathway...
Ch. 10.3 - Create a map or diagram that starts with a...Ch. 10.3 - Prob. 12CCCh. 10.3 - Are olfactory neurons pseudounipolar, bipolar, or...Ch. 10.3 - Prob. 14CCCh. 10.3 - Prob. 15CCCh. 10.4 - Prob. 16CCCh. 10.4 - Prob. 17CCCh. 10.5 - Prob. 18CCCh. 10.5 - Would a cochlear implant help a person who suffers...Ch. 10.5 - Prob. 20CCCh. 10.5 - Prob. 21CCCh. 10.5 - Prob. 22CCCh. 10.5 - Prob. 23CCCh. 10.6 - What functions do the aqueous humor serve?Ch. 10.6 - Prob. 25CCCh. 10.6 - Prob. 26CCCh. 10.6 - Prob. 27CCCh. 10.6 - Prob. 28CCCh. 10.6 - Prob. 29CCCh. 10.6 - Some vertebrate animals that see well in very low...Ch. 10.6 - Prob. 31CCCh. 10.6 - Macular degeneration is the leading cause of...Ch. 10.6 - Prob. 33CCCh. 10.6 - Draw a map or diagram to explain...Ch. 10 - What is the role of the afferent division of the...Ch. 10 - Prob. 2RQCh. 10 - Prob. 3RQCh. 10 - Prob. 4RQCh. 10 - Prob. 5RQCh. 10 - Prob. 6RQCh. 10 - Prob. 7RQCh. 10 - When a sensory receptor membrane depolarizes (or...Ch. 10 - Prob. 9RQCh. 10 - The organization of sensory regions in the _____...Ch. 10 - Prob. 11RQCh. 10 - Prob. 12RQCh. 10 - Prob. 13RQCh. 10 - Prob. 14RQCh. 10 - Prob. 15RQCh. 10 - Which structure of the inner ear codes sound for...Ch. 10 - Prob. 17RQCh. 10 - Prob. 18RQCh. 10 - Prob. 19RQCh. 10 - Prob. 20RQCh. 10 - Prob. 21RQCh. 10 - Prob. 22RQCh. 10 - Prob. 23RQCh. 10 - Prob. 24RQCh. 10 - Prob. 25RQCh. 10 - Trace the neural pathways involved in olfaction....Ch. 10 - Prob. 27RQCh. 10 - Prob. 28RQCh. 10 - Prob. 29RQCh. 10 - Map the following terms related to vision. Add...Ch. 10 - Prob. 31RQCh. 10 - Prob. 32RQCh. 10 - Prob. 33RQCh. 10 - Prob. 34RQCh. 10 - Prob. 35RQCh. 10 - Consuming alcohol depresses the nervous system and...Ch. 10 - Prob. 37RQCh. 10 - A clinician shines a light into a patients left...Ch. 10 - An optometrist wishes to examine a patients...Ch. 10 - The iris of the eye has two sets of antagonistic...Ch. 10 - As people age, their ability to see at night...Ch. 10 - The relationship between focal length (F) of a...
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