Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 10.5, Problem 18CC
Summary Introduction
To sketch The pathway followed by a sound wave from the outer ear to the auditory cortex.
Introduction: Ear is a sense organ that enables an individual to hear and maintains the equilibrium of the body. The outer ear of human is more advanced than any other mammals.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 10 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 10.1 - What advantage do myelinated axons provide?Ch. 10.1 - What accessory role does the outer ear (the pinna)...Ch. 10.1 - Prob. 3CCCh. 10.1 - In Figure 10.5, what kind(s) of ion channel might...Ch. 10.1 - How do sensory receptors communicate the intensity...Ch. 10.1 - Prob. 6CCCh. 10.2 - Prob. 7CCCh. 10.2 - Prob. 8CCCh. 10.2 - Your sense of smell uses phasic receptors. What...Ch. 10.3 - Create a map or diagram of the olfactory pathway...
Ch. 10.3 - Create a map or diagram that starts with a...Ch. 10.3 - Prob. 12CCCh. 10.3 - Are olfactory neurons pseudounipolar, bipolar, or...Ch. 10.3 - Prob. 14CCCh. 10.3 - Prob. 15CCCh. 10.4 - Prob. 16CCCh. 10.4 - Prob. 17CCCh. 10.5 - Prob. 18CCCh. 10.5 - Would a cochlear implant help a person who suffers...Ch. 10.5 - Prob. 20CCCh. 10.5 - Prob. 21CCCh. 10.5 - Prob. 22CCCh. 10.5 - Prob. 23CCCh. 10.6 - What functions do the aqueous humor serve?Ch. 10.6 - Prob. 25CCCh. 10.6 - Prob. 26CCCh. 10.6 - Prob. 27CCCh. 10.6 - Prob. 28CCCh. 10.6 - Prob. 29CCCh. 10.6 - Some vertebrate animals that see well in very low...Ch. 10.6 - Prob. 31CCCh. 10.6 - Macular degeneration is the leading cause of...Ch. 10.6 - Prob. 33CCCh. 10.6 - Draw a map or diagram to explain...Ch. 10 - What is the role of the afferent division of the...Ch. 10 - Prob. 2RQCh. 10 - Prob. 3RQCh. 10 - Prob. 4RQCh. 10 - Prob. 5RQCh. 10 - Prob. 6RQCh. 10 - Prob. 7RQCh. 10 - When a sensory receptor membrane depolarizes (or...Ch. 10 - Prob. 9RQCh. 10 - The organization of sensory regions in the _____...Ch. 10 - Prob. 11RQCh. 10 - Prob. 12RQCh. 10 - Prob. 13RQCh. 10 - Prob. 14RQCh. 10 - Prob. 15RQCh. 10 - Which structure of the inner ear codes sound for...Ch. 10 - Prob. 17RQCh. 10 - Prob. 18RQCh. 10 - Prob. 19RQCh. 10 - Prob. 20RQCh. 10 - Prob. 21RQCh. 10 - Prob. 22RQCh. 10 - Prob. 23RQCh. 10 - Prob. 24RQCh. 10 - Prob. 25RQCh. 10 - Trace the neural pathways involved in olfaction....Ch. 10 - Prob. 27RQCh. 10 - Prob. 28RQCh. 10 - Prob. 29RQCh. 10 - Map the following terms related to vision. Add...Ch. 10 - Prob. 31RQCh. 10 - Prob. 32RQCh. 10 - Prob. 33RQCh. 10 - Prob. 34RQCh. 10 - Prob. 35RQCh. 10 - Consuming alcohol depresses the nervous system and...Ch. 10 - Prob. 37RQCh. 10 - A clinician shines a light into a patients left...Ch. 10 - An optometrist wishes to examine a patients...Ch. 10 - The iris of the eye has two sets of antagonistic...Ch. 10 - As people age, their ability to see at night...Ch. 10 - The relationship between focal length (F) of a...
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