Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 1, Problem 73TQ
Summary Introduction

To review:

The number of possible decapeptides (a molecule with 10 amino acid residues linked by a peptide bond) that can be synthesized from 20 standard amino acids and the time taken by the task to calculate molecular structure of all the decapeptides.

Introduction:

There are hundreds and thousands of naturally occurring amino acids, but there are only 20 standard amino acids that take part in protein synthesis. Amino acids are joined to each other by a peptide bond. The resulting peptide formedby the polymerization of amino acids is called a polypeptide.

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Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  Can you please help show the titration curve for both of these peptides and calculate the PI?
Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  What is the structure of the PTH derivative produced during the last round of amino acid sequencing?
What is the primary sequence of this undecapeptide? Also,   if x-ray crystallography shows a highly stable hairpin turn within the polypeptide, what about the primary sequence explains this structural feature?
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