While R256T and K364R are at different positions, both mutations are present in the active site. Researchers were unable to get kinetics data on R256T. What does this tell you about its ability to function properly? Why might K364R be tolerated better than R256T?

While R256T and K364R are at different positions, both mutations are present in the active site. Researchers were unable to get kinetics data on R256T. What does this tell you about its ability to function properly? Why might K364R be tolerated better than R256T?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Q9
While R256T and K364R are at different positions, both mutations are
present in the active site. Researchers were unable to get kinetics
data on R256T. What does this tell you about its ability to function
properly? Why might K364R be tolerated better than R256T?

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