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Which statement is false for transition-state analog enzyme inhibitors? They fit the active site better than the substrate. Although they cannot perfectly mimic a transition state, they are important to the design of new pharmaceutical agents. Phosphoglycolohydroxamate inhibits the glycolytic enzyme aldolase nearly 10,000 times better than dihydroxyacetone phosphate. Due to noncovalent interactions with the active site, this type of inhibitor is reversible.

Which statement is false for transition-state analog enzyme inhibitors? They fit the active site better than the substrate. Although they cannot perfectly mimic a transition state, they are important to the design of new pharmaceutical agents. Phosphoglycolohydroxamate inhibits the glycolytic enzyme aldolase nearly 10,000 times better than dihydroxyacetone phosphate. Due to noncovalent interactions with the active site, this type of inhibitor is reversible.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Which statement is false for transition-state analog enzyme inhibitors? They fit the active site better than the substrate. Although they cannot perfectly mimic a transition state, they are important to the design of new pharmaceutical agents. Phosphoglycolohydroxamate inhibits the glycolytic enzyme aldolase nearly 10,000 times better than dihydroxyacetone phosphate. Due to noncovalent interactions with the active site, this type of inhibitor is reversible.
Transcribed Image Text:Which statement is false for transition-state analog enzyme inhibitors? They fit the active site better than the substrate. Although they cannot perfectly mimic a transition state, they are important to the design of new pharmaceutical agents. Phosphoglycolohydroxamate inhibits the glycolytic enzyme aldolase nearly 10,000 times better than dihydroxyacetone phosphate. Due to noncovalent interactions with the active site, this type of inhibitor is reversible.
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