Which of the following statement(s) is/are false/incorrect? You may select multiple options, if necessary. O Experiments support bidirectional movement of multiple replication forks at eukaryotic chromosomes. O Mg++ ions play important roles during DNA synthesis O Synthesis of DNA is semi-conservative ✔Beta clamp reduces DNA polymerase processivity ✔ DNA polymerase III uses ATP as a source of energy to drive the polymerization reaction forward O Tautomers enhance chances of correct nucleotide incorporation during DNA synthesis

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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### Which of the following statement(s) is/are false/incorrect? You may select multiple options, if necessary.

1. [ ] Experiments support bidirectional movement of multiple replication forks at eukaryotic chromosomes.
2. [ ] Mg++ ions play important roles during DNA synthesis.
3. [ ] Synthesis of DNA is semi-conservative.
4. [x] Beta clamp reduces DNA polymerase processivity.
5. [x] DNA polymerase III uses ATP as a source of energy to drive the polymerization reaction forward.
6. [ ] Tautomers enhance chances of correct nucleotide incorporation during DNA synthesis.

**Explanation of Graphs and Diagrams**: 

In this item, there are no graphs or diagrams to describe. 

### Explanation of Incorrect Statements:

#### Beta Clamp Reduces DNA Polymerase Processivity:
The beta clamp actually increases the processivity of DNA polymerase by tethering the polymerase to the DNA, allowing it to synthesize longer stretches of DNA without dissociating.

#### DNA Polymerase III Uses ATP as a Source of Energy to Drive the Polymerization Reaction Forward:
DNA polymerase III does not use ATP to drive the polymerization reaction. Instead, DNA synthesis is driven by the energy released when the high-energy phosphate bonds of the nucleotide triphosphates (dNTPs) are broken and the nucleotides are added to the growing DNA strand. The beta and gamma phosphates are released as pyrophosphate (PPi).
Transcribed Image Text:### Which of the following statement(s) is/are false/incorrect? You may select multiple options, if necessary. 1. [ ] Experiments support bidirectional movement of multiple replication forks at eukaryotic chromosomes. 2. [ ] Mg++ ions play important roles during DNA synthesis. 3. [ ] Synthesis of DNA is semi-conservative. 4. [x] Beta clamp reduces DNA polymerase processivity. 5. [x] DNA polymerase III uses ATP as a source of energy to drive the polymerization reaction forward. 6. [ ] Tautomers enhance chances of correct nucleotide incorporation during DNA synthesis. **Explanation of Graphs and Diagrams**: In this item, there are no graphs or diagrams to describe. ### Explanation of Incorrect Statements: #### Beta Clamp Reduces DNA Polymerase Processivity: The beta clamp actually increases the processivity of DNA polymerase by tethering the polymerase to the DNA, allowing it to synthesize longer stretches of DNA without dissociating. #### DNA Polymerase III Uses ATP as a Source of Energy to Drive the Polymerization Reaction Forward: DNA polymerase III does not use ATP to drive the polymerization reaction. Instead, DNA synthesis is driven by the energy released when the high-energy phosphate bonds of the nucleotide triphosphates (dNTPs) are broken and the nucleotides are added to the growing DNA strand. The beta and gamma phosphates are released as pyrophosphate (PPi).
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