Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.
Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.
Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Transcribed Image Text:Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a
G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the
replicative DNA polymerase reached xanthine on the template strand?
●
●
●
N
H
O
N
H
xanthine
NH
N
N
H
guanine
Answer Key: A
--
--- N
A. DNA polymerase would probably incorporate C opposite xanthine.
ZI
cytosne
B.
DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of
damage.
C. DNA polymerase would probably incorporate a base other than C opposite xanthine.
D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.
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