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Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.

Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● N N H N H xanthine NH N N H N H guanine H A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● ● ● N H O N H xanthine NH N N H guanine Answer Key: A -- --- N A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.
Transcribed Image Text:Spontaneous oxidative deamination of guanine produces the base xanthine (see figure, which also shows a G-C base pair). If DNA replication occurred before this damage was repaired, what would happen when the replicative DNA polymerase reached xanthine on the template strand? ● ● ● N H O N H xanthine NH N N H guanine Answer Key: A -- --- N A. DNA polymerase would probably incorporate C opposite xanthine. ZI cytosne B. DNA polymerase would stall, requiring a translesion DNA polymerase to synthesize DNA past the site of damage. C. DNA polymerase would probably incorporate a base other than C opposite xanthine. D. DNA polymerase would change the xanthine back to guanine using its proofreading activity.
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