Which of the following stages of T cell development would be affected in mice that have a genetic modification and do not express AIRE? CD4 SP and CD8 SP DN3 and DN4 DP DN1 and DN2 O O O O
Which of the following stages of T cell development would be affected in mice that have a genetic modification and do not express AIRE? CD4 SP and CD8 SP DN3 and DN4 DP DN1 and DN2 O O O O
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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
Transcribed Image Text:Which of the following stages of T cell development would be affected in mice that have a
genetic modification and do not express AIRE?
CD4 SP and CD8 SP
DN3 and DN4
DP
DN1 and DN2
0 0 0 0

Transcribed Image Text:Which of these best describes the DN3 stage of development?
Expression of pre-TCR; B-selection
Proliferation; a-chain locus rearrangement; becomes DP thymocyte
T-cell lineage commmitment
migration to thymus
oooo
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Step 1
Introduction :-
T cells are a type of white blood cell that play a critical role in the immune system. They are produced in the bone marrow and mature in the thymus gland. T cells are involved in cell-mediated immunity, which is the branch of the immune system that targets infected or abnormal cells within the body.
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