В-сel receptor Antigen Endosome- B-cell receptor binds to antigen. B cell degrades antigen into peptide fragments. B cell internalizes antigen. 5a -T-cell receptor Antigen fragment MHC class II TH cell recognizes antigen fragment and activates B cell. molecule Microbial antigen presented. Cytokine delivery Harmless antigen presented. 5b No TH cell recognizes antigen fragment; B cell becomes anergic. Peptide fragments are presented on MHC class II molecules. FIGURE 15.11 B-Cell Activation The B cell processes the antigen and presents it to TH cells. If a TH cell recognizes the antigen, it activates the B cell, allowing it to undergo clonal expansion.

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