5 Results in 8 10 6 T cell receptor complex Binds to 19 १ Results in H Activated ZAP-70 phosphorylates adaptor proteins •1,2,3,4 = Components •5= this binds to '6' along with 'I' • 6 = what does 'I' and 's bind to •7, 8, 9, 10 = Signal transduction steps
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- Cite evidence supporting a long evolutionary history for cell signaling molecules.N-term N- ER Signal Sequence Part of BHCC Protein N-terminus Middle of Protein C-terminus 19a. Which parts of the BHCC protein would be: Body Text 2* 2 BHCC PROTEIN SEQUENCE # ER Stop Transfer 3 A) inside the Rough ER organelle (in the ER lumen) B) inside the Rough ER membrane (transmembrane) C) in the cytosol $ Where it is located after translation (A, B, or C) ANSWER ANSWER ANSWER 4 Middle A B % 5 ER Start Transfer I MacBook Pro 6 "1"' & 7 FLEEEEE C-term CNon-canonical Hedgehog signaling results in actin cytoskeleton rearrangements, leading to cellmovement and changes in cell shape. Describe how changes to the actin cytoskeleton lead to cellmovement and changes in cell shape.You do not need to draw out the signaling pathway again (#1b). Your answer should focus onthe changes to the actin cytoskeleton. Drawings will be helpful!
- Synaptic transmission requires a vast number of molecular interactions taking place on both ends of synaptic cleft. Indicate each of the below molecules, events, or effects that is associated with the PRE-synaptic or POST-synaptic cell. a) Voltage-gated Ca2+ channel [Select] b) a-latrotoxin [Select] c) IPSP [Select] d) Endocannabinoid synthesis [Select] e) Acetylcholine synthesis [Select] f) BOTOX (botulinum toxin) [Select] g) Tetanus toxin [Select] h) Curare [Select] i) Signal amplification [Select] j) nicotinic acetylcholine receptor (nChR) [Select ]14 of 16 Which experimental technique would be useful in determining whether a particular chemical signal is a paracrine signal or not? Observation of the behaviour of single cells O Gene expression analysis Analysis of blood from nearby capillaries Chemical analysis of the signal molecule Analysis of extracellular fluid from the tissue in question# 3 You've engineered a mutant cell where the FADD adapter was truncated. The mutant FADD only contains the Death Domain, and lacks the Death Effector Domain. What is the most likely phenotypic outcome for this mutant cell when presented with the Fas ligand? 20 E O The Fas/FasL oligomer is formed, but apoptosis is blocked O The Fas/FasL oligomer is formed, and apoptosis is hyperactivated O The Fas/FasL oligomer is not formed, and apoptosis is blocked O The Fas/FasL oligomer is not formed, but apoptosis is hyperactivated F3 $ 4 DOD 000 R F4 % 5 F5 T BARAT 6 tv @ MacBook Air F6 Y & 7 F7 U * ➤11 8 F8 · 9 F9
- Compare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.In what way does the action of the membrane attack complexresemble the action of perforin?i) For serotonin receptor associated with the G protein class of subtype Gs, list the various ways how cell signalling can be terminated at stage 0 and 2 shown in Figure 1. 1 Reception ExtracellularA Hama Membra ely Malecle 2 Transduction 3 Response At Select by putting an arrow at the end of the correct choice(s). 2 a) - ) Cytoplase
- 7. A) What effect does the compound GppNHp, when applied to the inside of a cell during whole cell patch clamp recording, have on Cav2 channels at presynaptic terminals? B) What is the mechanism by which this compound affects G-protein signaling and Ca√2 channel activity? B. A.1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…TGF-B Receptor I (RI) phosphorylation of Smad2/3 does all of the following EXCEPT: activate Smad2/3 binding to the Co-Smad Smad4 dissociate intramolecular binding of Smad2/3 MH1 and MH2 domains. RI phosphorylation of Smad2/3 does all of these things. release Smad2/3 from the nucleus into the cytoplasm unmask the Smad2/3 nuclear localization signal (NLS).