Vhich statement about DNA methylation is true? D It requires a histone methylase. D It involves the modification of the pyrimidine cytosine. D It does not repress the transcription of genes. R It is not important in the development of mammalian embryos. D It is not abundant in promoters.
Vhich statement about DNA methylation is true? D It requires a histone methylase. D It involves the modification of the pyrimidine cytosine. D It does not repress the transcription of genes. R It is not important in the development of mammalian embryos. D It is not abundant in promoters.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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I'm between cytosine and promoters, why would option e be wrong?
Transcribed Image Text:**Question**: Which statement about DNA methylation is true?
- A) It requires a histone methylase.
- B) It involves the modification of the pyrimidine cytosine.
- C) It does not repress the transcription of genes.
- D) It is not important in the development of mammalian embryos.
- E) It is not abundant in promoters.
**Explanation**:
DNA methylation is primarily the addition of a methyl group to the cytosine base in the DNA sequence. It typically occurs in a CpG context in vertebrate genomes. The most relevant aspects of DNA methylation include:
- **Gene Regulation**: DNA methylation is known for its role in repressing gene transcription, particularly when occurring at promoter regions.
- **Development**: It is crucial in cellular differentiation and the development of organisms, especially in mammalian embryos.
- **Promoter Regions**: DNA methylation is generally abundant in promoter regions, playing a significant role in regulating gene expression.
The correct statement from the options is B) It involves the modification of the pyrimidine cytosine.
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