Using molecular biology techniques, it is possible to generate a strain of Drosophila fruit flies that lacks the alpha subunit of the hypoxia inducible factor (HIF-1). Compared to wild-type flies, what would be the metabolic consequence of exposing the HIF-1α deficient flies to a low oxygen (hypoxic) environment?
Q4. Using molecular biology techniques, it is possible to generate a strain of Drosophila fruit flies that lacks the alpha subunit of the hypoxia inducible factor (HIF-1).
Compared to wild-type flies, what would be the
A. The rate of conversion of pyruvate to lactate would be the same as hypoxic wild-type cells.
B. Since the beta subunit would be functional, inhibition of pyruvate decarboxylase complex activity would still occur.
C. The deficiency would result in a build-up of acetyl-CoA within the mitochondria.
D. The lack of HIF-1α would result in an increase in the rate of pyruvate uptake into mitochondria, triggering an increase in the rate of electron transport.
Step by step
Solved in 3 steps
