Transcribe and translate the mutated sequence #2. Determine the consequence, if any, for each mutation. You will need to use your codon charts in your ISN. Practice with both charts. Transcribe and translate the mutated sequence # 2. Determine the consequence, if any, for each mutation. You wiISN. Practice with both charts.Original DNAsequence:mRNA transcript:amino acids:Mutated DNAsequence #2:mRNA transcript:(Circle any changes)amino acids:Type ofmutation(Circle one.)How did themutation affectthe amino acidsequence(protein)?(Circle all thatapply.)#ARGPointTACAUGMETHTACSilent(Nochange)||||CUG #PROACCUGGTRPGACSubstitutionMissense(1 aminoacidchanged)#AUGTTGAACASNASNCTTNonsense(Prematurestop)signalGCGCGCARGGGCFrameshiftNo stopsignalACGUGCCYSGACGAC# CCG #GAA #GLUInserti1 amino acadded/deletedLE Mutated DNA sequence # 2 is an example ofHow did the mutation in sequence #2 affect the amino acid sequence (and as a result the protein)? Select ALL thSilent (No change)Missense (1 amino acid changed)Nonsense (Premature STOP sign)O No stop signalSubstitutionInsertionDeletionn 1 amino acid added/ deletedO All the amino acids changed after the mutation

Name: Transcribe and translate the mutated sequence #2. Determine the conse
Uploaded: 2024-03-20T06:42:55.000Z
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Description: Transcribe and translate the mutated sequence #2. Determine the consequence, if any, for each mutation. You will need to use your codon charts in your ISN. Practice with both charts. Transcribe and translate the mutated sequence # 2. Determine the

Let's scrutinize the mutated DNA sequence #2 concerning the original DNA sequence, the mRNA transcript, and the corresponding amino acid sequence.Original DNA sequence: TAC ACC TTG GCG ACG mRNA transcript: AUG UGG AAC CGC UGC Amino acids: Met Trp Asn Arg CysMutated DNA sequence #2: TAC GAC CTT GGC GAC GACa) Substitution: A substitution mutation involves replacing one nucleotide with another. By comparing the original and mutated DNA sequences, it's evident that the nucleotide "C" at position 4 has been substituted with "G" in the mutated sequence. Therefore, the mutation in sequence #2 is an exemplar of a substitution.b) Insertion: An insertion mutation occurs when one or more nucleotides are added to the DNA sequence. In mutated DNA sequence #2, there are no additional nucleotides inserted. Thus, option b) is not applicable.c) Deletion: A deletion mutation transpires when one or more nucleotides are removed from the DNA sequence. In the mutated DNA sequence #2, no nucleotides are deleted. Therefore, option c) is not applicable.let's evaluate the impact of the mutation on the amino acid sequence:Original amino acid sequence: Met Trp Asn Arg Cys Mutated amino acid sequence: Met Asp Leu Gly Asp Aspa) Silent (No change): A silent mutation arises when a nucleotide change doesn't alter the amino acid. In the mutated DNA sequence #2, there are no silent mutations since the substitution at position 4 leads to a different amino acid.b) Missense (1 amino acid changed): A missense mutation occurs when a nucleotide change results in a different amino acid. In the mutated amino acid sequence, the amino acid at position 3 changes from Asn to Asp. Therefore, option b) is applicable.c) Nonsense (Premature STOP signal): A nonsense mutation introduces a premature stop codon, leading to protein truncation. In the mutated amino acid sequence, there are no premature stop codons. Thus, option c) is not applicable.d) No stop signal: The presence of a premature stop codon would indicate a nonsense mutation. However, there are no premature stop codons in the mutated DNA sequence #2. Therefore, option d) is applicable.e) Amino acid added/deleted: The mutation doesn't result in the addition or deletion of amino acids. Therefore, option e) is not applicable.f) All the amino acids changed after the mutation: The mutated amino acid sequence shows changes in multiple amino acids, indicating alterations in protein composition. Therefore, option f) is applicable.The mutated DNA sequence #2 is an example of a substitution mutation. The mutation has resulted in a missense mutation and all the amino acids changed after the mutation.