Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
![Compute the **PERCENT IDENTITY** for the following pairwise sequence alignment.
Sequence 1: ACTGATGGGGG--AGACGTA
Sequence 2: ACTG--AAAAGCTAGACGTA
Alignment:
```
|||. ....| |||||||
```
**Explanation:**
- The vertical lines `|` indicate matching bases between the two sequences.
- The dots `.` represent mismatches.
**Steps to Calculate Percent Identity:**
1. Count the number of matching bases (vertical bars): 14
2. Count the total number of aligned positions, excluding gaps: 19
3. Calculate the percent identity using the formula:
\[
\text{Percent Identity} = \left( \frac{\text{Number of Matches}}{\text{Total Aligned Positions}} \right) \times 100
\]
**Conclusion:**
The percent identity here is approximately \( \frac{14}{19} \times 100 = 73.68\%\).](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F59577f62-52f2-4d8a-8fce-f8969dac81ff%2Ff22b3393-8379-4a32-9e2f-11e6cf178d88%2F3n6gxed_processed.png&w=3840&q=75)
Transcribed Image Text:Compute the **PERCENT IDENTITY** for the following pairwise sequence alignment.
Sequence 1: ACTGATGGGGG--AGACGTA
Sequence 2: ACTG--AAAAGCTAGACGTA
Alignment:
```
|||. ....| |||||||
```
**Explanation:**
- The vertical lines `|` indicate matching bases between the two sequences.
- The dots `.` represent mismatches.
**Steps to Calculate Percent Identity:**
1. Count the number of matching bases (vertical bars): 14
2. Count the total number of aligned positions, excluding gaps: 19
3. Calculate the percent identity using the formula:
\[
\text{Percent Identity} = \left( \frac{\text{Number of Matches}}{\text{Total Aligned Positions}} \right) \times 100
\]
**Conclusion:**
The percent identity here is approximately \( \frac{14}{19} \times 100 = 73.68\%\).
Expert Solution
Introduction
Pairwise sequence alignment allows alignment of two sequences of DNA, RNA and protein and aids in identifying similar regions. Such regions of similarity indicate functional/structural/evolutionary relationships between the sequences.
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