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The chain 3 subunit contains the amino acid sequence shown below. This sequence contains one alpha helix and the rest is random coil. Mark the region you believe will contain the alpha helix and explain your choice. In needed, feel free to use a helix wheel or other tools as part of your explanation. MNTFIIFIILIPIVGFALLAVNILLAVYKP

The chain 3 subunit contains the amino acid sequence shown below. This sequence contains one alpha helix and the rest is random coil. Mark the region you believe will contain the alpha helix and explain your choice. In needed, feel free to use a helix wheel or other tools as part of your explanation. MNTFIIFIILIPIVGFALLAVNILLAVYKP

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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### Amino Acid Sequence Analysis: Identifying Alpha Helix Regions #### Description: **Exercise:** The chain 3 subunit contains the amino acid sequence shown below. This sequence contains one alpha helix, while the rest is random coil. Mark the region you believe will contain the alpha helix and explain your choice. If needed, feel free to use a helix wheel or other tools as part of your explanation. **Amino Acid Sequence:** ``` MNTFIIFIILPIVGFALLAVNILLAVVKP ``` #### Instructions: 1. **Identify Alpha Helix Region:** - Analyze the given amino acid sequence. - Identify which segment of the sequence likely forms the alpha helix. 2. **Explanation:** - Explain your reasoning for selecting the specific region as an alpha helix. - Utilize tools such as the helix wheel, hydrophobicity scales, or any other relevant biochemical tools to support your choice. #### Tools and Tips: - **Helix Wheel:** A helix wheel can help visualize the helical structure and is useful for identifying patterns indicative of alpha helices. - **Hydrophobicity Scales:** Amino acids that are more hydrophobic (like alanine, leucine, and valine) tend to be found within alpha helices as these structures often reside inside proteins away from aqueous environments. By carefully analyzing the sequence with these tools, researchers and students can predict secondary structures, thereby enhancing their understanding of protein folding and function.
Transcribed Image Text:### Amino Acid Sequence Analysis: Identifying Alpha Helix Regions #### Description: **Exercise:** The chain 3 subunit contains the amino acid sequence shown below. This sequence contains one alpha helix, while the rest is random coil. Mark the region you believe will contain the alpha helix and explain your choice. If needed, feel free to use a helix wheel or other tools as part of your explanation. **Amino Acid Sequence:** ``` MNTFIIFIILPIVGFALLAVNILLAVVKP ``` #### Instructions: 1. **Identify Alpha Helix Region:** - Analyze the given amino acid sequence. - Identify which segment of the sequence likely forms the alpha helix. 2. **Explanation:** - Explain your reasoning for selecting the specific region as an alpha helix. - Utilize tools such as the helix wheel, hydrophobicity scales, or any other relevant biochemical tools to support your choice. #### Tools and Tips: - **Helix Wheel:** A helix wheel can help visualize the helical structure and is useful for identifying patterns indicative of alpha helices. - **Hydrophobicity Scales:** Amino acids that are more hydrophobic (like alanine, leucine, and valine) tend to be found within alpha helices as these structures often reside inside proteins away from aqueous environments. By carefully analyzing the sequence with these tools, researchers and students can predict secondary structures, thereby enhancing their understanding of protein folding and function.
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