The article "Improved Bioequivalence Assessment of Topical Dermatological Drug Products Using Dermatopharmacokinetics" (B. N’Dri-Stempfer, W. Navidi, R. Guy, and A. Bunge, Pharmaceutical Research, 2009:316–328) described a study comparing the amounts of econozole nitrate absorbed into human skin for several formulations of antifungal ointment. Both a brand name and generic drug were applied to the arms of 14 subjects, and the amounts absorbed, in ug/cm², were measured. Following are the results. Can you conclude that the mean amount absorbed differs between the brand name and the generic drug? Brand Name Generic Difference 2.23 1.42 0.81 1.68 1.95 -0.27 1.96 2.58 -0.62 2.81 2.25 0.56 1.14 1.21 -0.07 3.20 3.01 0.19 2.33 2.76 -0.43 4.06 3.65 0.41 2.92 2.89 0.03 2.92 2.85 0.07 2.83 2.44 0.39 3.45 3.11 0.34 2.72 2.64 0.08 3.74 2.82 0.92

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The article "Improved Bioequivalence Assessment of Topical Dermatological Drug
Products Using Dermatopharmacokinetics" (B. N’Dri-Stempfer, W. Navidi, R. Guy, and A.
Bunge, Pharmaceutical Research, 2009:316–328) described a study comparing the amounts
of econozole nitrate absorbed into human skin for several formulations of antifungal
ointment. Both a brand name and generic drug were applied to the arms of 14 subjects, and
the amounts absorbed, in ug/cm², were measured. Following are the results. Can you
conclude that the mean amount absorbed differs between the brand name and the generic
drug?
Brand Name
Generic
Difference
2.23
1.42
0.81
1.68
1.95
-0.27
1.96
2.58
-0.62
2.81
2.25
0.56
1.14
1.21
-0.07
3.20
3.01
0.19
2.33
2.76
-0.43
4.06
3.65
0.41
2.92
2.89
0.03
2.92
2.85
0.07
2.83
2.44
0.39
3.45
3.11
0.34
2.72
2.64
0.08
3.74
2.82
0.92
Transcribed Image Text:The article "Improved Bioequivalence Assessment of Topical Dermatological Drug Products Using Dermatopharmacokinetics" (B. N’Dri-Stempfer, W. Navidi, R. Guy, and A. Bunge, Pharmaceutical Research, 2009:316–328) described a study comparing the amounts of econozole nitrate absorbed into human skin for several formulations of antifungal ointment. Both a brand name and generic drug were applied to the arms of 14 subjects, and the amounts absorbed, in ug/cm², were measured. Following are the results. Can you conclude that the mean amount absorbed differs between the brand name and the generic drug? Brand Name Generic Difference 2.23 1.42 0.81 1.68 1.95 -0.27 1.96 2.58 -0.62 2.81 2.25 0.56 1.14 1.21 -0.07 3.20 3.01 0.19 2.33 2.76 -0.43 4.06 3.65 0.41 2.92 2.89 0.03 2.92 2.85 0.07 2.83 2.44 0.39 3.45 3.11 0.34 2.72 2.64 0.08 3.74 2.82 0.92
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