Suppose we define the Alzheimer's disease phenotype as being diagnosed with the disease by age 75 years. In the human population, there are three alleles of the ApoE gene: e2, e3, e4. They form an allelic series such that: 70% of 75 year olds with the e4/e4 genotype have the Alzheimer's phenotype 60% of 75 year olds with the e3/e4 genotype have the Alzheimer's phenotype 40% of 75 year olds with the e3/e3 genotype have the Alzheimer's phenotype 30% of 75 year olds with the e2/e4 genotype have the Alzheimer's phenotype 10% of 75 year olds with the e2/e3 genotype have the Alzheimer's phenotype If I have the e4/e4 genotype and my wife has the e2/e3 genotype, what is the probability that our child will have Alzheimer's by age 75. Explain your reasoning.

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