, within specific regional populations over two thousand years ago, sickle-cell anemia killed those individuals born with it before they could reproduce to pass it on to offspring, how did it persist in these populations?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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If, within specific regional populations over two thousand years ago, sickle-cell anemia killed those individuals born with it before they could reproduce to pass it on to offspring, how did it persist in these populations? 
Group of answer choices
A-Because of late-onset of the disease.
B-Because it is cause by a virus and it spreads faster than people died.
C-Because of the basic principles of mendelian inheritance that result in some heterozygote "carrier" combinations.
D-Because malaria made it possible to survive sickle cell anemia since the parasite would carry oxygen on the blood cells with the mutated hemoglobin.
E-It does not persist. Natural selection removes the allele because people die from both malaria and sickle-cell anemia.
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