Suppose that the gene for a protein 500 amino acids in length undergoes a mutation. If the mutation causes the synthesis of amutant protein in which just one of the 500 amino acids is incorrect, the protein may lose its biological function.How can a small change in a protein's sequence inactivate the protein?The catalytic site of the protein may be malformed, preventing complementary fit.RNA may not recognize the altered DNA sequence, and bases may pair incorrectly.It may alter the shape of the protein's molecular chaperone, preventing proper protein folding.The active site may base pair incorrectly with the complementary DNA strand.The resulting protein may fold incorrectly and may not attain its native conformation.

Proteins are composed of amino acids. They are linked together by peptide linkages. Proteins have…

Answered: Suppose that the gene for a protein 500…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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What enzyme catalyzes protein synthesis in bacteria? You discover a new broad-spectrum antibiotic that inhibits protein synthesis and named it Compound J. You want to determine the mechanism of action of Compound J. After treating bacteria cells with Compound J, you observe many ribosomes with long polypeptide chains bound to them. Based on this observation, make a hypothesis about which part of the ribosome Compound J is binding and how this specifically affects translation. What evidence supports that proper protein folding is essential to all domains of life? Name and describe the function/s of two specific molecules that help proteins fold in bacteria.
A protein had the amino acids leu-gly at codons 10 and 11. A deletion of the 5’ base of the leu codon (i.e. the first base) changed the protein so that it now reads ser-ala at codons 10 and 11. The original Leu codon must have been: (hint: make use of a codon table to answer this question) CUG AUG CUA CUC CUU
Refer to the genetic code table and the mRNA sequence below to complete this question: U C U G A U G G G C U U U... beginning with the start codon, which amino acids, in order, are coded for by this section of mRNA? A) Thr-Met- Gly B) Met-Gly-Phe C) Ser-Asp-Gly-Leu .
Describe translation in eukaryotes by answering each part below: - What are the players (the most important enzymes, proteins, or components)? And what does each do (specifically)? - Describe each of the three stages of translation in your own words. Be sure to include the key players in your description. - Provide one similarity between prokaryote and eukaryotic translation and two differences.
While the three previous paragraphs put on some details about enzymes, a Russian physician and chemist named Phoebus Levene focused on the three major components of a single nucleotide (phosphate, pentose sugar, and nitrogenous base) in 1919. He was also the first to discover the carbohydrate component of RNA (ribose), and carbohydrate component of DNA (deoxyribose). Years later, Levene finally identified how DNA and RNA molecules are put together Then in 1937, Hans Krebs discovered the most famous (probably) process that occur during cell respiration. This series of chemical reactions has three names such as the Citric Acid Cycle, Tricarboxylic Acid Cycle and Krebs Cycle. In this process, glucose and oxygen is converted to carbon dioxide, water, and energy. While working on bacterial samples, Oswald Avery first suggested in 1944 that the genetic material of the cell was possibly the deoxyribonucleic acid. In the middle of the 20th Century, Erwin Chargaff began to oppose Levene's…
Which of the following are TRUE for RNA compared to DNA? Please select ALL correct answer options. Select 4 correct answer(s) Question 6 options: RNA contains the bases A, G, C, and U, whereas DNA contain the bases A, G, C, and T. RNA can catalyze biological reactions, but DNA cannot. DNA but not RNA can bind proteins RNA has ribose sugar in its nucleotides, rather than the deoxyribose found in DNA. RNA is usually single stranded and can make more complex three-dimensional molecular shapes than double-stranded DNA.
Phosphorylation is a very common post-translational modication (PTM) to regulate protein function. Which amino acids are most commonly regulated by phosphorylation? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Leucine, arginine, serine. b Tyrosine, arginine, glutamine. C Serine, threonine, tyrosine. d Glutamine, arginine, tyrosine. e Serine, tyrosine, glutamine.
Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in
Shown below is a cartoon of a genetic oscillator. a) Convert into a Forrester diagram, state variables are D, m, E, S and P. As a reminder, dashed lines serve control/regulation. b) In a sentence, what causes the cyclic behavior in the formation of the product? DNA D mRNA Enzyme Substrate Product I 3
3)Which of the following statements are true? Choose all that apply a)There are multiple codons possible for nearly all amino acids b)Each stop codon also codes for an amino acid c)Each tRNA will base pair with only one codon d)The start codon also codes for an amino acid e)Each codon in mRNA codes for exactly one amino acid f)Each codon in tRNA codes for exactly one amino acid g)Each anticodon in tRNA pairs with exactly one codon h)Each tRNA carries exactly one type of amino acid
What is the correct sequence in translation? a tRNA attaches to start codon, ribosome attaches to mRNA in P site, new tRNA enters on A site, peptide chain moves to old tRNA in P site, old tRNA moves to E and new tRNA to P. b tRNA attaches to start codon, ribosome attaches to mRNA in P site, new tRNA enters on A site, peptide chain moves to new tRNA, old tRNA moves to E and new tRNA to P. c tRNA attaches to start codon, ribosome attaches to mRNA in A site, new tRNA enters on P site, peptide chain moves to new tRNA, old tRNA moves to E and new tRNA to A. d tRNA attaches continuously to mRNA without the need of a ribosome. Proteins are: a the direct translation of a single gene b in most cases, the results of post-translation control c first transcribed from DNA by an operon d transcription factors Which of the following statements is false? a In the lytic cycle, new phage are produced and released into the environment. b…
Consider Molecule X, which is found in all living cells. Each form of this molecule is keyed to the genetic code for a particular amino acid. When activated, the amino acid is covalently bonded to one end of this molecule, and it carries the amino acid to a ribosome to take part in protein assembly. What is the name of X? Your answer should be one word, or a short two- or three-word phrase. Spelling counts. Note: if there is more than one possible answer, separate each answer with a comma. 0

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