what is the Role of ATM in the cell and cancer ? sites on the slilymerase is nassembly facteproteins all inloader. Thus,the enzymes tl40. Which repair system is tightly coupled to transcription? Why is it important to repRNA polymerase quickly?41. What is translesion DNA synthesis and when is it used? Why is it a last resort? DcdsDNA?42. What are the steps of homologous recombination repair? Which proteins are invhomologous sequences and how do they function?DNA SYNTEAt the replicesimultaneous)SSDNA preserof DNA is brvmuch more di43. What are the steps of nonhomologous end joining?44. When is NHEJ used as a mechanism for DNA repair? Why is it a last resort? Doeover, repair ofChapter 10).45. Describe the general steps needed for a cell to become cancerous.46. How do mutations and chromosomal abnormalities affect proteins and lead to47. What role do cell cycle checkpoints have in cancer?48. Define a tumor suppressor apnd oncogene and give an example ofeach.49. Define the role of ATM in the cell and cancer.NHEJ. Which is preferred and why?Upon DNA damage, ATM decide

Answered: sites on the sli lymerase is n assembly…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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what is the Role of ATM in the cell and cancer ?

sites on the sli
lymerase is n
assembly facte
proteins all in
loader. Thus,
the enzymes tl
40. Which repair system is tightly coupled to transcription? Why is it important to rep
RNA polymerase quickly?
41. What is translesion DNA synthesis and when is it used? Why is it a last resort? Dc
dsDNA?
42. What are the steps of homologous recombination repair? Which proteins are inv
homologous sequences and how do they function?
DNA SYNTE
At the replice
simultaneous)
SSDNA preser
of DNA is brv
much more di
43. What are the steps of nonhomologous end joining?
44. When is NHEJ used as a mechanism for DNA repair? Why is it a last resort? Doe
over, repair of
Chapter 10).
45. Describe the general steps needed for a cell to become cancerous.
46. How do mutations and chromosomal abnormalities affect proteins and lead to
47. What role do cell cycle checkpoints have in cancer?
48. Define a tumor suppressor apnd oncogene and give an example of
each.
49. Define the role of ATM in the cell and cancer.
NHEJ. Which is preferred and why?
Upon DNA damage, ATM decide

Expert Solution

Step 1

ATM gene which stands for Ataxia-Telangiectasis Mutated gene is a gene which is responsible for intentifying DNA damages in the cells and initiate its repair. The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1.

Thus, it is of utmost importance to the cell.

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