Scenario 1: Dyskeratosis congenita (DKC) is a rare human genetic disorder affecting telomere replication. Mutations in the genes encoding telomerase enzymes result in telomeres with RNA subunits that do not read 3'-CAACCCCAAC-5'. DKC symptoms include bone marrow failure (reduced production of blood cells) and anemia. If symptoms are severe, a bone marrow transplant may be the only form of effective treatment. Question 4: To explain how mutations in genes encoding telomerase RNA subunits could lead to bone marrow failure, answer the two questions below. I am only expecting single sentence answers for this question. A. When an RNA subunit on telomerase does not function, what happens to the length of the chromosome over time? B. Why might this mutation be more of a problem in rapidly dividing cells like hematopoietic stem cells?
Scenario 1: Dyskeratosis congenita (DKC) is a rare human genetic disorder affecting telomere replication. Mutations in the genes encoding telomerase enzymes result in telomeres with RNA subunits that do not read 3'-CAACCCCAAC-5'. DKC symptoms include bone marrow failure (reduced production of blood cells) and anemia. If symptoms are severe, a bone marrow transplant may be the only form of effective treatment. Question 4: To explain how mutations in genes encoding telomerase RNA subunits could lead to bone marrow failure, answer the two questions below. I am only expecting single sentence answers for this question. A. When an RNA subunit on telomerase does not function, what happens to the length of the chromosome over time? B. Why might this mutation be more of a problem in rapidly dividing cells like hematopoietic stem cells?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Scenario 1: Dyskeratosis congenita (DKC) is a rare human genetic disorder affecting
telomere replication. Mutations in the genes encoding telomerase enzymes result in
telomeres with RNA subunits that do not read 3'-CAACCCCAAC-5'. DKC symptoms
include bone marrow failure (reduced production of blood cells) and anemia. If
symptoms are severe, a bone marrow transplant may be the only form of effective
treatment.
Question 4: To explain how mutations in genes encoding telomerase RNA subunits
could lead to bone marrow failure, answer the two questions below. I am only expecting
single sentence answers for this question.
A. When an RNA subunit on telomerase does not function, what happens to the
length of the chromosome over time?
B. Why might this mutation be more of a problem in rapidly dividing cells like
hematopoietic stem cells?
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