Critically discuss the following statement: ‘The success of PARP inhibitor therapy in ovarian cancer has led to the development of novel synthetic lethal strategies targeting DNA damage response in solid tumours’. Include challenges of PARP inhibition therapy as well as future developments in your answer.

Q: Gene expression array technology has been used to do which of the following (select all that apply)?…

A: Gene expression array technology is a technology used to measure the expression level of thousands…

Q: Give 4 examples of transcription factors / non-structural proteins you have learned in this course?…

A: Since you have posted multiple questions we solve the first two questions for you. To get the…

Q: Looking at this statement, develop an argument and critically evaluate/discuss it, then discuss…

A: Cancer is a complex disease characterized by genetic mutations, abnormal cell growth, and defective…

Q: d. What does ‘transfection’ mean? e. What are ‘single clones’ and how did various single clones…

A: de novo DNA methylation is the addition of methyl groups to specific sites in the promoter region of…

Q: A deletion mutation occuring in the region of DNA which encodes for a sigma subunit of RNA…

A: Mutation is sudden, heritable change in the sequence of the genome that give rise to alternate form…

Q: researchers identified the important role of GNAQ in both development and cancer

A: GNAQ is G Protein subunit Alpha Q.It is a protein coded gene present on chromosome 9.It is a guanine…

Q: Among the following statements regarding the use of viral vectors, which is (are) true: (can be more…

A: Transfer of foreign nucleic acid insert into the eukaryotic cell is transfection. For many…

Q: Suggest how the researchers could have altered their targeting construct, to ensure that all of the…

A: To ensure that all of the neomycin resistant transformants would have generated the expected PCR…

Q: Briefly describe the following properties of the Ras GTPases: a) Size, structure and cellular…

A: a) Mature ras protein are located on the inner side of the plasma membrane, and their biochemical…

Q: (b) How many forms can naturally occurring DNA exist in? Explain how these forms are characterized.…

A: DNA  Deoxyribonucleic acid  Genetic material in many species Has ds(double stranded) structure…

Q: Many resistance mechanisms are encoded on plasmids. These mechanisms are of great clinical…

A: BLAST is a bioinformatics tool that enables us to identify a gene if we know its DNA sequence or the…

Q: 3). Consider the four mutations (i-iv) described below: i. One of the mutations causing cystic…

A: A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur…

Q: Using Figure 20-17, explain how the mutation in theGATA sequence of the Duffy gene imparts…

A: Mutation refers to any alteration in the sequence of DNA. It can either be caused by errors that…

Q: Meta analysis C9orf72 Known Novel • 20 15 10 SARM1UNC13A МОВР GPX3-TNIP1 -LOC101927815- SCFD1- 5 CO…

A: ALS (Amyotrophic Lateral Sclerosis) is a group of rare neurological disease. It involves  the motor…

Q: Based on the NCBI Blastp and reciprocal analysis, are there any mutations to suggest that mus…

A: In thе contеxt of tеsting thе human FGFR3 gеnе in Mus musculus, NCBI Blastp and rеciprocal analysis…

Q: Which of the following best describes the approach that wasused in the first gene therapy trial for…

A: SCID means severe combined immunodeficiency. It is a group of rare disorders which are caused due to…

Q: 3) Whole-mount in situ hybridization can be used to test for the function of non-coding DNA region.…

A: * Whole mount in situ hybridization is a tool that aids for temporal and spatial dissection of gene…

Q: a.) Which of the following molecules would you need to mutate a gene with non-homologous chromosomal…

A: Gene expression is defined as the process by which genetic data encoded inside a gene is used to…

Q: Cloned human embryonic stem cells would be useful for which of the following reasons: Group of…

A: Introduction :- Cloning is a process of making the genetically identical copies of cell / tissue /…

Q: The antagonist of the inhibitor in down regulation is called: A. repressor B. promoter C. inducer D.…

A: explanation-An decrease in the number of receptors on the surface of target cells making the cells…

Q: methyltransferase (TPMT) levels is correct? 27. In the context of 6-mercaptopurine (6-MP) therapy…

A: 6-Mercaptopurine (6-MP) is an important drug used in the treatment of leukemia and other conditions.…

Q: Briefly describe the effects of colchicine treatment on cells. What are the genetic implications of…

A: Colchicine is a medication that is commonly used to treat gout and other inflammatory conditions. It…

Q: The phenotype of a maternal effect gene is expressed in Select one: O a. The F1 offspring ob. In…

A: Sir Gregor Mendel was a priest and a teacher who did the famous hybridization experiment on garden…

Q: Current therapeutic interventions that aim to address the impact of mutations on gene function

A: Mutations in the gene functions results in various diseases. Mutations does not allow some of the…

Q: The ability to selectively modify the genome in the mouse has revolutionized mouse genetics. Outline…

A: Molecular biology's applications include the development of new protein products, illness prevention…

Q: 1. Match each of the terms in the left column to the bestfitting phrase from the right column.a.…

A: The terms given in the left column are related to the genetic material of an organism. Genetic…

Q: a. Briefly discuss (using three sentences) how the concepts and/or techniques in molecular biology…

A: As COVID-19 was discovered in Hubei Province, China, in December 2019, COVID-19 has spread…

Q: You have a patient slated to undergo somatic cell gene therapy to alleviate a cystic fibrosis…

A: Answer: Cystic fibrosis is the result of homozygous recessive mutations in the CFTR gene.

Q: he steps to replicate the identified spike protein are as follows: . Find the CDNA sequence of the…

A: Gene expression is a phenomenon in which gene is expressed into a particular protein. It is a very…

Q: Explain how site directed mutagenesis can be accomplished using M13 bacteriophage. Using this method…

A: Deoxyribonucleic acid (DNA) is a hereditary molecule that passes genetic information from one…

Q: How does bisulfite treatment coupled with PCR enable the identification of DNA methylation? And, How…

A: DNA methylation is an essential epigenetic process that plays a key role in various biological…

Q: Which of the candidate genes would be good targets to develop potential therapeutics using SİRNA…

A: According to the question, we have to mention which of the candidate genes would be good targets to…

Q: 8. Which of the following is the most common way in which a genetic mutation occurs? a. Point…

A: Mutations are changes that occur in the genetic material of an organism such as DNA or RNA. These…

Q: Despite the failure to date of gene therapy, identification of the gene responsible for cystic…

A: Cystic fibrosis (CF) is a genetic disease caused by a mutation in the CFTR (cystic fibrosis…

Q: Jonah and Jana are siblings. Jonah has the genetic disorder cystic fibrosis, caused by inheriting…

A: Cystic fibrosis is an inherited genetic disorder that damages the lungs and digestive system.

Q: It has been suggested that it would make the study of human diseases easier if cloned transgenic…

A: Transgenic animals These animals have one or more sequences of DNA from another species have been…

Q: Describe how HpaII and MspI can be used to determine if a given DNA sequence is methylated. Any…

A: HpaII and MspI are two useful enzymes used to detect methylation in a given DNA sequence. These…

Q: Of the genes in the microarray shown in the lower part of Figure 20.10, are most overexpressed or…

A: Introduction: Microarray is a technique employed to study the expression of various genes. With the…

Q: A current focus of molecular medicine is to trigger or promote apoptosis of specific cells. several…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: K-RAS mutation can be used as an early detection marker for molecular diagnosis and risk assessment…

A: Gene alteration within organisms by the use of genetic engineering techniques is termed as…

Q: Q2) A. As long as the optimum dosage of the ionizing radiation is achieved it can be used for…

A: Cancer is characterized by the uncontrolled or uninterrupted growth and division of body cells…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.