Consider which of the five mutations is most likely to cause Duchenne muscular dystrophy in this family. Would this mutation affect the process of replication? Would this mutation affect the process of transcription? Would this mutation affect the process of translation? Explain your reasoning.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Consider which of the five mutations is most likely to cause Duchenne muscular dystrophy in this family.

Would this mutation affect the process of replication?

Would this mutation affect the process of transcription?

Would this mutation affect the process of translation?

Explain your reasoning. 

EXON
intron
EXON
5'-acgcggtctatattagctcaCAAGATGTACTTTGCGACAAGAGAGgtaagtcttgtccagGATCCCATCTGTGCGACTTGAACG(terminator)-3'
3'-tgcgccagatataatcgagtGTTCTACATGAAACGCTGTTCTCTCcattcagaacaggtcCTAGGGTAGACACGCTGAACTTGC(terminator)-5'
个
Transcription
Start Site (+1)
#1
# 2
A>G
#3
#4
#5
g>a
C>A
a>t
G>C
Transcribed Image Text:EXON intron EXON 5'-acgcggtctatattagctcaCAAGATGTACTTTGCGACAAGAGAGgtaagtcttgtccagGATCCCATCTGTGCGACTTGAACG(terminator)-3' 3'-tgcgccagatataatcgagtGTTCTACATGAAACGCTGTTCTCTCcattcagaacaggtcCTAGGGTAGACACGCTGAACTTGC(terminator)-5' 个 Transcription Start Site (+1) #1 # 2 A>G #3 #4 #5 g>a C>A a>t G>C
Normalized
Dystrophin
MRNA levels
Affected
Unaffected
Transcribed Image Text:Normalized Dystrophin MRNA levels Affected Unaffected
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