Consider which of the five mutations is most likely to cause Duchenne muscular dystrophy in this family. Would this mutation affect the process of replication? Would this mutation affect the process of transcription? Would this mutation affect the process of translation? Explain your reasoning.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question

Consider which of the five mutations is most likely to cause Duchenne muscular dystrophy in this family.

Would this mutation affect the process of replication?

Would this mutation affect the process of transcription?

Would this mutation affect the process of translation?

Explain your reasoning. 

EXON
intron
EXON
5'-acgcggtctatattagctcaCAAGATGTACTTTGCGACAAGAGAGgtaagtcttgtccagGATCCCATCTGTGCGACTTGAACG(terminator)-3'
3'-tgcgccagatataatcgagtGTTCTACATGAAACGCTGTTCTCTCcattcagaacaggtcCTAGGGTAGACACGCTGAACTTGC(terminator)-5'
个
Transcription
Start Site (+1)
#1
# 2
A>G
#3
#4
#5
g>a
C>A
a>t
G>C
Transcribed Image Text:EXON intron EXON 5'-acgcggtctatattagctcaCAAGATGTACTTTGCGACAAGAGAGgtaagtcttgtccagGATCCCATCTGTGCGACTTGAACG(terminator)-3' 3'-tgcgccagatataatcgagtGTTCTACATGAAACGCTGTTCTCTCcattcagaacaggtcCTAGGGTAGACACGCTGAACTTGC(terminator)-5' 个 Transcription Start Site (+1) #1 # 2 A>G #3 #4 #5 g>a C>A a>t G>C
Normalized
Dystrophin
MRNA levels
Affected
Unaffected
Transcribed Image Text:Normalized Dystrophin MRNA levels Affected Unaffected
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON