**Question:**Resident ER proteins destined to remain in the lumen of the ER are marked by retrieval sequences, and if these proteins are exported from the ER to the Golgi, they are recognized by a recycling receptor in the ERGIC or the Golgi and selectively returned to the ER.**Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer.**a) Trueb) False

Name: **Question:**Resident ER proteins destined to remain in the lumen of
Uploaded: 2024-03-20T06:42:41.000Z
Channel: Bartleby
Description: **Question:**Resident ER proteins destined to remain in the lumen of the ER are marked by retrieval sequences, and if these proteins are exported from the ER to the Golgi, they are recognized by a recycling receptor in the ERGIC or the Golgi and sel

The "Endoplasmic reticulum(ER) plays an important role, and it is where the membranes and their component proteins are synthesized." The Endoplasmic reticulum contains the enzymes required for lipid synthesis, and lipids generated in the ER are inserted into the organelle's own membranes.Answer: True Explanation: Resident ER proteins with KDEL retrieval sequences at the carboxy terminus are identified by ERGIC or the Golgi and preferentially restored to the ER (e.g., BiP contains an aiming sequence [KDEL or KKXX] at the carboxy terminus that guides recovery directly to the ER). The KDEL motif, which is found at the very C-terminus of soluble ER proteins, is both required and adequate for retention and retrieval.Conclusion: The soluble ER-resident protein is captured by the KDEL receptor in the Golgi and transported back to the ER in a COP I-coated vesicle. KDEL is also seen in vesicular tubular clusters.