Report the effect of lowering extracellular glucose levels on each molecule or enzyme shown below.A. Phosphofructokinase 2[ Select ]B. Fructose Bisphosphatase 2 [ Select ]C. Glucagon [Select ]D. CAMP [Select ]E. Pyruvate Kinase[ Select ]> V [ Select ]ŠelectActivatedUneffectedDeactivated

A. Phosphofructokinase 2 is deactivated when the extracellular glucose level is lowered. B.…

Answered: Report the effect of lowering…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Mutations in glucokinase which lower the kcat for the enzyme or elevate the Km for glucose result in mild to moderate elevation of blood glucose. Explain how these mutations cause diabetes-like symptoms in patients.
Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. 5 Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # Pyruvate are added to the co-enzyme and whereas Carbon # of leaves as CO» The C-2 unit together with the co-enzyme is called transferred to the 2nd co-enzyme 11 12 The C-2 unit is then which is initially in its state. The enzyme that catalyzes this step is From here, the C-2 unit is transferred to form a linkage with CoA-SH to generate Acetyl COA Oxidized Hydroxyethyl TPP Phosphodiester Reduced Hydroxypropiony! TPP Lipoamide E-1 NADH 3 Dihydrolipoyl dehydrogenase Thioester 2 HydroxyacetyITPp Dihydropipoyl Transacetylase Type the words in the correct order separated by commas. Example: 1, 3, E-1, Thioester, Lipoamide ...
Which of the following are correct responses to low cellular energy charge? Choose all that apply. a Decreased catalytic activity of pyruvate carboxylase b Decreased flux through the citric acid cycle C d e Multiple answers: Multiple answers are accepted for this question f & Increased PDH complex activity Decreased use of citrate for fatty acid synthesis Decreased catalytic activity of pyruvate kinase Decreased activity of PDH kinase Decreased conversion of oxaloacetate to malate
A certain type of tumor results in the overproduction of glucagon. Researchers claim that treatment with insulin can counteract the effects of the excess glucagon on the pathway shown in Figure 2. Provide reasoning to justify the researchers' claim.
The reactions of the pyruvate dehydrogenase complex are required to generate the substrate that is fed into the TCA (Kreb’s) cycle from pyruvate. The 3 enzymes that make up this complex are pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2) dihydrolipoyl dehydrogenase (E3). a. Name the one diffusible reaction product (i.e. the product that is free to leave the enzyme complex) of each enzyme of the complex. b. Draw the “business end” of the fully reduced form of lipoic acid. c. Using words, fully describe the function of E3 in this complex. Your answer should include all cofactors used, all intermediates and products of this enzyme. DO NOT show any mechanisms for this part.
In the indicated tissues, how will each process or the activity of each enzyme below be affected by the signal sent upon Glucagon secretion? Use an up (t) or down (1) arrow or NC (no change). (Hint: Decide what pathways will be up-regulated first, then look at the enzymes below!) + Triacylglygerol Lipase (Adipocytes) Phosphofructokinase-2 (Liver) Insulin secretion (Pancreas) Pyruvate Kinase (Muscle) Glycogen Phosphorylase (Liver) Phosphofructokinase-1 (Liver) Fructose-1,6-bisphosphatase 1 (Liver) Fatty Acid Biosynthesis (Liver) PEP Carboxxkinase (Liver) Phosphorylation of Perilipins (Adipocytes) Adenylate Cyclase (Liver) Glycogen Synthase (Liver) Acetyl CoA Carboxylase Hexokinase II (Muscle)
64 An investigator is studying the mechanism of action of an insulin-sensitizing drug. The addition of the drug to cultured mouse hepatocytes is observed, and results show increased phosphorylation and inhibition of acetyl-CoA carboxylase Which of the following processes is most likely inhibited by this action of the drug? A) Fatty acid oxidation B) Fatty acid synthesis C) Glycogen synthesis D) Glycolysis E) Protein synthesis
Glucose 6-phosphatase deficiency is a glycogen storage disease referred to as von Gierke disease. Which of the following symptoms would you NOT expect to see in patients with this disease? (A) severe fasting hypoglycemia (B) excess adipose triglyceride storage and low circulating levels of fatty acids (C) hyperammonemia (D) liver enlargement resulting from excess liver glycogen storage (E) lactic acidosis (F) gout
Consider regulation of glycolysis vs gluconeogenesis in the liver. Which of the following are more likely to promote the activity of gluconeogenesis rather than glycolysis? (select all that apply) Group of answer choices An increase in the ATP/AMP ratio A decrease/lack of F-2,6-BP The cell is in a low energy state Insulin signaling Glucagon signaling An abundance of citric acid cycle intermediates (i.e. citrate) Intense exercise Inhibition of pyruvate carboxylase Fasting
Glucose-6-phosphate isomerase is used to do which of the following steps of glycolysis Select one: a. Glucose-6-phosphate is converted to Fructose-6-phosphate b. 3-phosphoglycerate is converted 2-phosphoglycerate c. Glyceraldehyde-3-phosphate is converted to 1,3 Bisphosphoglycerate d. Glucose is converted to Glucose-6-phosphate e. Dihydroxyacetone (Glycerone Phosphate) is converted to Glyceraldehyde-3-phosphate f. Fructose-1,6 Bisphosphate is converted to Dihydroxyacetone and Glyceraldehyde-3-phosphate g. 1,3 Bisphosphoglycerate is converted to 3-phosphoglycerate h. Phosphoenolpyruvate is converted to pyruvate i. Fructose-6-phosphate is converted to Fructose-1,6,bisphosphate j. 2-phosphoglycerate is converted to Phosphoenolpyruvate
Regulation of the pyruvate dehydrogenase complex (PDH) is dependent on indicators of energy charge (i.e. ATP/ADP ratio) and redox status (i.e. NADH/NAD* ratio). Answer the following questions about regulation of the PDH. a. The PDH is subject to regulation by a kinase and a phosphatase. Upon phosphorylation by the kinase, activity of PDH is reduced. Removal of the phosphoryl by the phosphatase increases activity of PDH. For the following metabolites, select whether the kinase that acts upon PDH is likely to be allosterically activated or inhibited by the molecule. ATP: [Select] NADH: [Select] b. When oxygen is depleted, the electron transport chain does not flow. What effect would these conditions have on activity of the PDH and why? (note, superscript does not work in the dropdown menu so NAD+ = NAD*) What effect?: [Select] Why?: [Select]
Why would LDH be up- or down-regulated depending on location of cancer cells? Anaerobic cancer cells enhance rates of ATP production and rely on pyruvate to lactate conversion. LDH5 expressed can vary in favoring pyruvate for conversion to lactate (anaerobic metabolism). Aerobic compartments in newly formed fibrobasts and vessels use lactate to convert to pyruvate for oxidative phosphorylation and favor lactate conversion to pyruvate by LDH1 (aerobic metabolism). Lactate dehydrogenase is upregulated in both cancer cells and supporting stroma and vessels, thus only LDH5 is upregulated showing enhanced expression levels and thus presence at the plasma membrane to increase levels of lactate for export, LDH1 levels are always consistent. LDH1 is upregulated in response to the export of lactate by MCT1, while LDH5 is down-regulated Neither LDH1 or LDH5 are both consistently expressed, regardless of oxygen levels

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Report the effect of lowering extracellular glucose levels on each molecule or enzyme shown below. A. Phosphofructokinase 2 [ Select ] B. Fructose Bisphosphatase 2 [ Select ] C. Glucagon [ Select ] D. CAMP [Select ] E. Pyruvate Kinase [ Select ] >