0000Refer to figure 1D of the Science Article. Which produces the greatest inhibition of PDE (phosphodiesterase activity)DPDE activity(percent inhibition)8040IBMX (•): 3-isobutylmethylxanthine, syntheticCaffeine (A): naturally present in plantsTheophylline (o): naturally present in smallamounts in tea and cocoa beans, used to treatasthma8-phenyltheophylline (0): synthetic, works by adifferent mechanism.0 0.0010.10.01Methylxanthine (mM)IBMXCaffeineTheophylline8-phenyltheophylline1.0

In the experiment described, the researchers tested the inhibitory effects of different…

Answered: Refer to figure 1D of the Science…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A. Which one of the following is an example of affinity chromatography? Select all that apply. a) Hormone – receptor interaction b) Enzyme – substrate interaction c) Antigen-antibody interaction d) All of the above e) Cytochrome C – DEAE matrix B. If your sepharose beads are covalently attached to adrenaline hormone, which of the following protein is most likely purified by affinity chromatography? a) Receptor tyrosine kinase (RTK) b) Calmodulin c) GPCR d) Protein kinase A C. Which of the following malate dehydrogenase (MDH) has a 'peptide epitope tag'? a) MDH-HA b) MDH-GST c) MDH-GFP e) All of them D. To elute target proteins from an affinity chromatography matrix, which of the following conditions would be the most appropriate? a) Low salt concentrations b) High salt concentrations c) Adding a soluble ligand that competes with the affinity tagged protein for binding to the column d) Just keep washing buffer through the column, isocratic elution
Consider the metabolic pathway show below that converts substrate A to B with the enzyme A-ase, B to C with B-ase(I), and so forth. Acety/A-ase Acetate - A-ase Deacetylase A-ase Protease & C-ase B-ase ABCD What is the mechanism of regulation of B-ase? Positive allostery Reversible Covalent modification Isoenzymes Proteolytic Activation Feedback Inhibition 1
You are working for a drug discovery company. Your team has identified a derivative (you will be given a randomly selected compound from the table below) of aspirin/paracetamol, has optimal physicochemical properties for biological activity. To conduct preliminary tests on the drug candidate you are required to synthesise the derivative from benzene. Propose a synthetic pathway starting from benzene to the candidate drug. Important: your company wants efficiency, a synthetic, pathways that provide good yield (major product) and are energy efficient (if possible, avoid pathways that involve working with lots of ring deactivating groups) is preferred. H3CO HO O
. The following data, presented by G. Bowes and W. L. Ogre in J. Biol. Chem. (1972) 247:2171–2176, describe the relative rates of incorpo- ration of CO, by rubisco under N, and under pure O,. Decide whether O, is a competitive or uncompetitive inhibitor. [CO,] (mM) Under N2 Under O, 0.20 16.7 10 0.10 12.5 5.6 0.067 8.3 4.2 0.050 7.1 3.2
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Tetrodotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.
Describe the categories of enzyme control: (image provided) Allosteric control with example Covalent modification with example
Amoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit ADP, and activate myosin II) is found toward the rear of the cell. Based on your…
Please handraw this graph with all the necessary detailed information: Imagine that I text enzyme rate for four different temperatures: 10 degrees celsius, 20 degrees celsisus, 30 degree celsius, and 40 degree celsius, in separate tubes. The enzyme appears to work faster as temperature increases, but completely ceases activity at 40 degrees celcius. Sketch a graph to show this outcome, but here you will graph product formation (nmoles/mL) vs. time (minutes). The graph should be 4 lines and HANDDRAWN. Include a legend if necessary. You do not need precise quantitivate values, but most show the correct trends on the graph.
Triclosan is a broad-spectrum antibacterial agent used in many household products. It is structurally similar to polychlorobiphenylol, a substrate that binds to the active site of the enzyme sulfotransferase. Based on these facts, you can conclude that triclosan most likely: lowers the activation energy of chemical reactions. functions as an enzyme when sulfotransferase is absent. is a competitive inhibitor. acts as a noncompetitive inhibitor.
Batrachotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Please provide sources in APA format
Which of the following statements are true? (This is a multi- select question, select all that apply). Carbohydrates serve mainly for short-term energy storage; TAGs serve mainly for long-term energy storage. Both carbohydrates and TAGS serve other important roles, such as in molecular recognition. Both carbohydrates and TAGS serve important roles as second messengers. Carbohydrates can be used to produce ATP much more quickly than TAGS can. TAGS are a much more efficient way to store energy (you can get more ATP on a "per weight" basis).

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