0000Refer to figure 1D of the Science Article. Which produces the greatest inhibition of PDE (phosphodiesterase activity)DPDE activity(percent inhibition)8040IBMX (•): 3-isobutylmethylxanthine, syntheticCaffeine (A): naturally present in plantsTheophylline (o): naturally present in smallamounts in tea and cocoa beans, used to treatasthma8-phenyltheophylline (0): synthetic, works by adifferent mechanism.0 0.0010.10.01Methylxanthine (mM)IBMXCaffeineTheophylline8-phenyltheophylline1.0

In the experiment described, the researchers tested the inhibitory effects of different…

Answered: Refer to figure 1D of the Science…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Which of the following statements about sugar polymers and glycosaminoglycans is/are true? Glucosamine, an amino sugar, would be positively charged physiologically unless it is part of an amide bond. Chitin is a homopolymer of GlcNac in beta 1--> 4 linkages. Amylose is a homopolymer of glucose containing alpha 1--> 6 linkages. Amylopectin in a non-reducing sugar polymer consisting solely of glucose monomers. Agarose is a highly charged sugar polymer used in electrophoresis. A core of hyaluronan protein is linked to an aggrecan polysaccharide in the extracellular matrix around joints and tendons. Mucins are secreted proteins that contain branched oligosaccharides linked to serine residues. None of the options shown is true. The glycosaminoglycan "hyaluronic acid" would carry more negative charge overall when compared to a polymer of "chondroitin" of the same length. Please answer very soon will give rating surely Complete Answer needed
Plants in the genus Ephedra have been harvested for their active substance ephedrine for centuries. Ephedrine is used to reduce the symptoms of bronchitis and asthma, as a stimulant and study aid, and as an appetite suppressant. It is also the main ingredient in the illegal production of methamphetamine. Since 2006, the sale of ephedrine and related substances has been limited and monitored in the United States. One effect of ingesting ephedrine is greatly increased metabolism, which has been known to kill users of ephedrine. How might an increased metabolic rate cause death?
A. Which one of the following is an example of affinity chromatography? Select all that apply. a) Hormone – receptor interaction b) Enzyme – substrate interaction c) Antigen-antibody interaction d) All of the above e) Cytochrome C – DEAE matrix B. If your sepharose beads are covalently attached to adrenaline hormone, which of the following protein is most likely purified by affinity chromatography? a) Receptor tyrosine kinase (RTK) b) Calmodulin c) GPCR d) Protein kinase A C. Which of the following malate dehydrogenase (MDH) has a 'peptide epitope tag'? a) MDH-HA b) MDH-GST c) MDH-GFP e) All of them D. To elute target proteins from an affinity chromatography matrix, which of the following conditions would be the most appropriate? a) Low salt concentrations b) High salt concentrations c) Adding a soluble ligand that competes with the affinity tagged protein for binding to the column d) Just keep washing buffer through the column, isocratic elution
Suppose, drug A has a molecular weight <100 Da, in which pathway it should get absorbed? Write an overview on that pathway with graphical representation where necessary.
Polyketide Biosynthesis: Provide a separate sheet for the proposed biosynthetic pathway. 1.) Plumbagin is a natural product derived through polyketide synthesis via acetat pathway. It is a yellow dye isolated from a medicinal plant Plumbago zeylanica L. It is a naphthoquinone derived-metabolite known to exhibit inhibitory activity against prostate cancer. Following polyketide pathway: OH A.) Create or propose a biosynthetic route for the production of plumbagin B.) Identify the precursors and the number of precursors required in the synthesis of metabolite
Consider the metabolic pathway show below that converts substrate A to B with the enzyme A-ase, B to C with B-ase(I), and so forth. Acety/A-ase Acetate - A-ase Deacetylase A-ase Protease & C-ase B-ase ABCD What is the mechanism of regulation of B-ase? Positive allostery Reversible Covalent modification Isoenzymes Proteolytic Activation Feedback Inhibition 1
You are working for a drug discovery company. Your team has identified a derivative (you will be given a randomly selected compound from the table below) of aspirin/paracetamol, has optimal physicochemical properties for biological activity. To conduct preliminary tests on the drug candidate you are required to synthesise the derivative from benzene. Propose a synthetic pathway starting from benzene to the candidate drug. Important: your company wants efficiency, a synthetic, pathways that provide good yield (major product) and are energy efficient (if possible, avoid pathways that involve working with lots of ring deactivating groups) is preferred. H3CO HO O
. The following data, presented by G. Bowes and W. L. Ogre in J. Biol. Chem. (1972) 247:2171–2176, describe the relative rates of incorpo- ration of CO, by rubisco under N, and under pure O,. Decide whether O, is a competitive or uncompetitive inhibitor. [CO,] (mM) Under N2 Under O, 0.20 16.7 10 0.10 12.5 5.6 0.067 8.3 4.2 0.050 7.1 3.2
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Tetrodotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.
Describe the categories of enzyme control: (image provided) Allosteric control with example Covalent modification with example

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