Question 8 of 26 Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent intera NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI ionic interaction Species able to form that NCI any species with permanent dipoles (C=O, etc.) H bonded to N, O, or F and a lone pair on N, O, or F Answer Bank Parameters affecting the NCI strength and orientation of dipole orientation polarizability, size: molecular weight

Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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Question 8 of 26
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactio
(NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions.
Type of NCI
ionic interaction
dipole-dipole
Species able to form that NCI
any
species with permanent
dipoles (C=O, etc.)
H bonded to N, O, or F and
a lone pair on N.O.or F
Answer Bank
dielectric size; type of charge
ions; charged species
hp
dispersion
Parameters affecting the NCI
hydrogen bond
strength and orientation
of dipole
orientation
polarizability; size; molecular weight
Transcribed Image Text:Question 8 of 26 Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactio (NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI ionic interaction dipole-dipole Species able to form that NCI any species with permanent dipoles (C=O, etc.) H bonded to N, O, or F and a lone pair on N.O.or F Answer Bank dielectric size; type of charge ions; charged species hp dispersion Parameters affecting the NCI hydrogen bond strength and orientation of dipole orientation polarizability; size; molecular weight
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