Q.1 Three given polypeptides (P, Q and R ), of same size and same pl (7.2), have a single aspartic acid in each of them. In polypeptide P, the aspartic acid residue is on the surface. In polypeptide Q, it is surrounded by negatively charged residues, whereas in polypeptide R it is deeply buried in a hydrophobie core. pKa of the side chain carboxylate of free (in solution) aspartic acid is 3.65. The polypeptides are in a buffer of pH 7.4. The clange in pKa of tlhe aspartic acid side chain carboxylate in the polypeptides P, Q and R is likely to Ans remain the same in P, modest increase in Q and greater increase in R 2. remain the same in all the three polypeptides X 3. increase in P, decrease in Q and remain the same in R X 4. remain the same in P, increase Q and decrease in R

Q.1 Three given polypeptides (P, Q and R ), of same size and same pl (7.2), have a single aspartic acid in each of them. In polypeptide P, the aspartic acid residue is on the surface. In polypeptide Q, it is surrounded by negatively charged residues, whereas in polypeptide R it is deeply buried in a hydrophobie core. pKa of the side chain carboxylate of free (in solution) aspartic acid is 3.65. The polypeptides are in a buffer of pH 7.4. The clange in pKa of tlhe aspartic acid side chain carboxylate in the polypeptides P, Q and R is likely to Ans remain the same in P, modest increase in Q and greater increase in R 2. remain the same in all the three polypeptides X 3. increase in P, decrease in Q and remain the same in R X 4. remain the same in P, increase Q and decrease in R

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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